# Effects of Blood Flow Restriction Training on Cardiopulmonary Function and Body Composition: A Systematic Review with Meta-Analysis

**Authors:** Kun Yang, Chen Soon Chee, Johan bin Abdul Kahar, Tengku Fadilah Tengku Kamalden, Rui Li, Shaowen Qian

PMC · DOI: 10.5114/jhk/204824 · Journal of Human Kinetics · 2025-05-29

## TL;DR

This study finds that blood flow restriction training improves lung function and muscle growth in athletes but does not significantly affect heart function or body measurements.

## Contribution

The study provides a meta-analysis on the effects of blood flow restriction training on cardiopulmonary and body composition outcomes in athletes.

## Key findings

- BFRT moderately improved pulmonary function and muscle hypertrophy in athletes.
- No significant improvements were observed in cardiac function or anthropometric measures.
- Training variables like duration and frequency significantly influenced the effectiveness of BFRT.

## Abstract

The aim of this meta-analysis was to investigate the effects of blood flow restriction training (BFRT) on cardiopulmonary function and body composition of athletes and active participants. Based on the PRISMA guidelines, we searched four international databases for literature up to November 2024, assessed methodological quality using the PEDro scale, and used RevMan 5.4 software for data analysis, publication bias evaluation as well as subgroup analysis. A meta-analysis of forty well-assessed quality studies involving a total of 839 athletes and active participants aged 14–33 years was conducted. The results revealed that BFRT moderately improved both pulmonary function (ES = 0.81–0.88; p < 0.01) and muscle hypertrophy (ES = 0.73–0.74; p < 0.01), while no significant improvement was found for cardiac function (ES = −0.30–0.35; p > 0.05) and anthropometric measures (ES = 0.02–0.04; p > 0.05). Subgroup analyses showed that the moderator variables (training status, age, duration, frequency, training type, and cuff pressure) also had small to large significant effects on pulmonary function and muscle hypertrophy (ES = 0.55–1.74; p < 0.05). In conclusion, BFRT positively affected cardiopulmonary function and body composition in athletes and active participants with significant improvements in pulmonary function and muscle hypertrophy, but not in cardiac function and anthropometric measures. BFRT was more beneficial for improving these physiological metrics when applied to young trained participants with intervention duration of less than six weeks and frequency of fewer than three sessions per week..

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, EPO (erythropoietin) [NCBI Gene 2056] {aka DBAL, ECYT5, EP, MVCD2}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}
- **Diseases:** muscle damage (MESH:D009133), injury (MESH:D014947), muscle (MESH:D019042), ischemia (MESH:D007511), hypoxia (MESH:D000860), obese (MESH:D009765), hypoxic (MESH:D002534), hypertrophy (MESH:D006984), cardiovascular disease (MESH:D002318), Muscle Hypertrophy (MESH:C536106), BFRT (MESH:D002313)
- **Chemicals:** lactate (MESH:D019344), oxygen (MESH:D010100), calcium (MESH:D002118), carbon dioxide (MESH:D002245)

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12946869/full.md

## References

85 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946869/full.md

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Source: https://tomesphere.com/paper/PMC12946869