# In vitro evaluation of a self-positioning individualized titanium mesh for improved accuracy in guided bone regeneration

**Authors:** Jiayuan Zhang, Yufan Chen, Xingru Tao, Kaihang Zhang, Chunfeng Xu, Dedong Yu

PMC · DOI: 10.3389/fbioe.2026.1718616 · Frontiers in Bioengineering and Biotechnology · 2026-02-13

## TL;DR

A new self-positioning titanium mesh improves accuracy in bone regeneration for dental implants in lab tests.

## Contribution

A self-positioning 3D-printed titanium mesh is introduced for more accurate guided bone regeneration.

## Key findings

- The self-positioning mesh reduced contour deviations compared to conventional methods.
- It improved screw placement accuracy and reduced volumetric discrepancies.
- 2D analysis showed better vertical and horizontal bone augmentation accuracy.

## Abstract

Adequate bone volume and contour are essential for successful implant placement. This study evaluated the accuracy of a novel self-positioning three-dimensional printed individualized titanium mesh (3D-PITM) in guided bone regeneration (GBR).

Ten identical maxillary phantoms with standardized defects were divided into an experimental self-positioning 3D-PITM group and a conventional 3D-PITM group. Pre- and postoperative CBCT scans were obtained for 3D reconstruction and superimposition. Deviations in augmented contours, screw placement, volumetric accuracy, and 2D cross-sectional augmentation were analyzed.

The self-positioning group showed significantly reduced deviation in augmentation contours (0.82 ± 0.07 mm vs. 1.02 ± 0.13 mm, P = 0.003), improved screw placement accuracy (0.10 ± 0.13 mm vs. 0.65 ± 0.32 mm, P = 0.026), and lower volumetric discrepancies. Two-dimensional evaluation confirmed greater vertical and horizontal accuracy in bone augmentation (P = 0.021, P = 0.018).

The self-positioning 3D-PITM achieved more accurate installation and predictable bone augmentation in vitro, suggesting potential clinical advantages for implant-supported rehabilitation.

## Full-text entities

- **Diseases:** edentulism (MESH:D007575), periodontitis (MESH:D010518), trauma (MESH:D014947), maxillary defects (MESH:D008439), alveolar bone defect (MESH:D016301), bone defect (MESH:D001847), alveolar (MESH:D002282), tooth extraction (MESH:D014076)
- **Chemicals:** NaCl (MESH:D012965), Zirconium (MESH:D015040), Ti (MESH:D014025)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bos taurus (bovine, species) [taxon 9913]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12946736/full.md

## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946736/full.md

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Source: https://tomesphere.com/paper/PMC12946736