# Dysbiosis in the Family nucleus of Children Diagnosed With Autism Spectrumin Mexico City

## TL;DR

This study explores the gut microbiome similarities between children with autism and their parents, suggesting a potential link through shared microbiota.

## Contribution

The study reveals that children with autism have gut microbiomes more similar to their mothers' than their fathers', suggesting a potential heritable microbiome pattern.

## Key findings

- The gut microbiome of children with ASD was found to be more similar to their mothers' microbiomes.
- Microbiome analysis was conducted using QIIME2 and DADA2 on stool samples from three ASD families.
- The findings suggest a potential heritability of ASD through microbiome transmission from parents.

## Abstract

The relationship between the gut microbiome and Autism Spectrum Disorder (ASD) has been the subject of growing interest in scientific research. Research into the relationship between the gut microbiome and ASD has gained relevance in recent years as recent studies have identified significant differences in the gut microbiome abundance and composition in ASD children compared to neurotypical ones. However, little is known about the microbiome interplay, changes and relationship in parents and children with ASD, considering that they share a consistent environment. Charactering the microbiota of trio-type families with a child diagnosed with autism.

The hypervariable region of the 16s ribosomal gene was sequenced from stool samples from adolescents with ASD and their parents. The analysis was performed using various software programs, including QIIME2 and DADA2.

In this paper, we discuss this relationship in three families, and observed that the gut microbiome of the offspring with ASD is more similar to the mother's than the father's microbiome.

These observations could lead to the understanding of the potential heritability of the disorder through parental connectedness of the gut microbiome and eventually to the development of interventions aimed at modulating the gut microbiota to improve symptoms associated with ASD.