# Histological and clinical evaluation of novel deproteinized porcine bone mineral in socket preservation: a case report

**Authors:** Jie Chen, Lina Xu, Zixiao Wang, Qing Wang

PMC · DOI: 10.3389/froh.2026.1719449 · Frontiers in Oral Health · 2026-02-13

## TL;DR

This case report shows that deproteinized porcine bone mineral helps preserve jawbone structure after tooth extraction and supports successful dental implant placement.

## Contribution

The study demonstrates the clinical and histological effectiveness of deproteinized porcine bone mineral in socket preservation.

## Key findings

- DPBM preserved alveolar ridge dimensions better than the non-treated site.
- Histological analysis showed new bone formation and integration with DPBM particles.
- A dental implant placed after DPBM treatment achieved stable osseointegration.

## Abstract

Socket preservation, also known as alveolar ridge preservation, is a crucial dental procedure aiming to minimize the resorption of the alveolar ridge following tooth extraction. The use of bone substitutes has reduced the morbidity at the donor areas by decreasing the necessity of autogenous bone grafts and improved the patients' satisfaction and comfort. This case report aimed to evaluate the clinical and histological efficacy of deproteinized porcine bone mineral (DPBM) for socket preservation following molar extraction. A 48-year-old male patient underwent extraction of tooth #17 (maxillary left second molar), followed by socket preservation using DPBM. For comparative purposes, the patient's contralateral tooth #27 (maxillary right second molar) was extracted without socket preservation. After a 3-month follow-up, clinical evaluation revealed satisfactory dimensional stability of the alveolar ridge at the #17 site (bone height: 6.9 mm; bone width reduction: 7.4 mm), whereas the #27 site exhibited significant resorption (bone height: 6.4 mm; bone width: 6.9 mm). Histological analysis via Masson trichrome staining demonstrated new bone formation and tight integration between the DPBM particles and host bone at the #17 site. Subsequently, a dental implant was successfully placed at the preserved socket 4 months post-preservation, with stable osseointegration and functional restoration at the 1-year follow-up. This case confirms the effectiveness of DPBM in maintaining alveolar ridge dimensions and promoting new bone formation, providing a reliable foundation for subsequent implant therapy.

## Full-text entities

- **Diseases:** cardiovascular diseases (MESH:D002318), infection (MESH:D007239), bone loss (MESH:D001847), alveolar ridge resorption (MESH:D016301), Tooth extraction (MESH:D014076), diabetes (MESH:D003920), inflammation (MESH:D007249), pain (MESH:D010146), autoimmune disorders (MESH:D001327)
- **Chemicals:** DPBM (-), Bio-Oss (MESH:C077540), formalin (MESH:D005557), ibuprofen (MESH:D007052), chlorhexidine (MESH:D002710), amoxicillin (MESH:D000658)
- **Species:** Homo sapiens (human, species) [taxon 9606], Bos taurus (bovine, species) [taxon 9913]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12946667/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946667/full.md

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Source: https://tomesphere.com/paper/PMC12946667