# Clinical, Prognostic, and Biological Features of High‐Risk Cardiometabolic Phenotype: The REMODEL Study **Authors:** Adam A. R. Muhammad, Jia Kai Chuan, Aisyah Latib, Jennifer A. Bryant, Vivian Lee, Redha Boubertakh, Thu‐Thao Le, Calvin W. L. Chin PMC · DOI: 10.1002/mco2.70631 · MedComm · 2026-02-26 ## Full-text entities - **Genes:** TNFRSF13B (TNF receptor superfamily member 13B) [NCBI Gene 23495] {aka CD267, CVID, CVID2, IGAD2, RYZN, TACI}, VSIG2 (V-set and immunoglobulin domain containing 2) [NCBI Gene 23584] {aka 2210413P10Rik, CTH, CTXL}, NPPB (natriuretic peptide B) [NCBI Gene 4879] {aka BNP, Iso-ANP}, PWAR1 (Prader Willi/Angelman region RNA 1) [NCBI Gene 145624] {aka D15S227E, PAR-1, PAR1}, EPHB4 (EPH receptor B4) [NCBI Gene 2050] {aka CMAVM2, HFASD, HTK, LMPHM7, MYK1, TYRO11}, IL2RA (interleukin 2 receptor subunit alpha) [NCBI Gene 3559] {aka CD25, IDDM10, IL2R, IMD41, TCGFR, p55}, ANGPT1 (angiopoietin 1) [NCBI Gene 284] {aka AGP1, AGPT, AGPT-1, ANG1, HAE5}, LGALS9 (galectin 9) [NCBI Gene 3965] {aka HUAT, LGALS9A}, LTBR (lymphotoxin beta receptor) [NCBI Gene 4055] {aka D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP}, TNFRSF10B (TNF receptor superfamily member 10b) [NCBI Gene 8795] {aka CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2}, CSTB (cystatin B) [NCBI Gene 1476] {aka CPI-B, CST6, EPM1, EPM1A, PME, STFB}, MMP7 (matrix metallopeptidase 7) [NCBI Gene 4316] {aka MMP-7, MPSL1, PUMP-1}, PDCD1LG2 (programmed cell death 1 ligand 2) [NCBI Gene 80380] {aka B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2}, AXL (AXL receptor tyrosine kinase) [NCBI Gene 558] {aka ARK, AXL3, JTK11, Tyro7, UFO}, GDF15 (growth differentiation factor 15) [NCBI Gene 9518] {aka GDF-15, HG, MIC-1, MIC1, NAG-1, PDF}, CHI3L1 (chitinase 3 like 1) [NCBI Gene 1116] {aka ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P}, SPON2 (spondin 2) [NCBI Gene 10417] {aka DIL-1, DIL1, M-SPONDIN, MINDIN}, CD93 (CD93 molecule) [NCBI Gene 22918] {aka C1QR1, C1qR(P), C1qRP, CDw93, ECSM3, MXRA4}, HSPB1 (heat shock protein family B (small) member 1) [NCBI Gene 3315] {aka CMT2F, HEL-S-102, HMN2B, HMND3, HS.76067, HSP27}, TNFRSF1A (TNF receptor superfamily member 1A) [NCBI Gene 7132] {aka CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, IL18BP (interleukin 18 binding protein) [NCBI Gene 10068] {aka FVH, IL18BPa} - **Diseases:** endothelial dysfunction (MESH:D014652), diabetes mellitus (MESH:D003920), cardiometabolic diseases (MESH:D024821), fibrosis (MESH:D005355), inflammation (MESH:D007249), acute coronary syndromes (MESH:D054058), dyslipidemia (MESH:D050171), visceral adiposity (MESH:D007418), essential hypertension (MESH:D000075222), strokes (MESH:D020521), inherited cardiomyopathies (MESH:D009202), atrial fibrillation (MESH:D001281), cardiovascular disease (MESH:D002318), insulin resistance (MESH:D007333), vascular dysfunction (MESH:D002561), Death (MESH:D003643), left ventricular hypertrophy (MESH:D017379), hypertension (MESH:D006973), adiposity (MESH:D018205), heart failure (MESH:D006333), cardiac remodeling (MESH:D020257), hypertrophic (MESH:D002312) - **Chemicals:** NT-proBNP (-), glucose (MESH:D005947), gadolinium (MESH:D005682), lipid (MESH:D008055) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12946451/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12946451/full.md ## References 5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946451/full.md --- Source: https://tomesphere.com/paper/PMC12946451