# Severe pneumoperitoneum, mediastinal emphysema, and thoracoabdominal wall emphysema during flexible bronchoscopy: a case report

**Authors:** Jun Yang, Mei Yao, Baolong Lu, Dong Huang, Lu Yang, Guohou Zhao

PMC · DOI: 10.3389/fmed.2026.1744405 · Frontiers in Medicine · 2026-02-13

## TL;DR

A rare case of severe air leakage complications during bronchoscopy is reported, emphasizing the importance of careful oxygen delivery and monitoring.

## Contribution

This case report highlights a rare complication of flexible bronchoscopy and offers insights into its management.

## Key findings

- The patient developed pneumoperitoneum, mediastinal emphysema, and thoracoabdominal wall emphysema during bronchoscopy.
- Conservative treatment and multidisciplinary resuscitation led to stabilization and eventual discharge.
- No gastrointestinal perforation or pneumothorax was observed, suggesting alternative mechanisms for the complications.

## Abstract

This case presents a rare complication that occurred during flexible bronchoscopy, including severe pneumoperitoneum, mediastinal emphysema, and thoracoabdominal wall emphysema. This study provides a profound analysis of the most probable causes of the aforementioned complications, hoping to offer some valuable insights for clinical practice. The patient developed abdominal distension, abdominal bulge, decreased oxygen saturation, and hemodynamic instability during flexible bronchoscopy under intravenous anesthesia with oxygen delivery via a nasopharyngeal oxygen cannula at a flow rate of 5 L/min. Following a multidisciplinary resuscitation procedure involving the insertion of an endotracheal tube, the administration of vasoactive medications, and the performance of an abdominal paracentesis, the patient’s condition demonstrated signs of stabilisation. Imaging studies revealed pneumoperitoneum, mediastinal emphysema, and thoracoabdominal wall emphysema, but no pneumothorax was observed. Additionally, no endoscopically visible gastrointestinal perforation was detected. The patient was finally discharged after improvement with conservative treatment. This report aims to explore the potential mechanisms and management strategies for this rare complication, highlighting the need for vigilance against barotrauma and careful management of oxygen delivery methods during bronchoscopy.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CALCA (calcitonin related polypeptide alpha) [NCBI Gene 796] {aka CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT}, NPPB (natriuretic peptide B) [NCBI Gene 4879] {aka BNP, Iso-ANP}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}
- **Diseases:** infectious diseases (MESH:D003141), dry rales (MESH:D012135), Abdominal distension (MESH:D000007), sleep apnea-hypopnea syndrome (MESH:D020181), chronic pulmonary or cardiac disease (MESH:D006331), perforations (MESH:D057112), interstitial lung disease (MESH:D017563), gastrointestinal injury (MESH:D005767), chills (MESH:D023341), peritonitis (MESH:D010538), pneumothorax (MESH:D011030), infection (MESH:D007239), ulcer (MESH:D014456), cough (MESH:D003371), barotrauma (MESH:D001469), respiratory distress (MESH:D012128), fever (MESH:D005334), bronchospasm (MESH:D001986), airway obstruction (MESH:D000402), hereditary diseases (MESH:D030342), esophageal injury (MESH:D004941), hemorrhage (MESH:D006470), hemoptysis (MESH:D006469), hyperemia (MESH:D006940), alveolar rupture (MESH:D012421), malignant tumors (MESH:D009369), cyanosis (MESH:D003490), Shortness of breath (MESH:D004417), emphysema (MESH:D004646), pneumoperitoneum (MESH:D011027), pulmonary infection (MESH:D012141), respiratory diseases (MESH:D012140)
- **Chemicals:** alcohol (MESH:D000438), HCO3 (MESH:D001639), Lidocaine (MESH:D008012), vasoactive medications (-), sufentanil citrate (MESH:D017409), propofol (MESH:D015742), epinephrine (MESH:D004837), Oxygen (MESH:D010100)
- **Species:** Influenza A virus (no rank) [taxon 11320], Homo sapiens (human, species) [taxon 9606], Haemophilus influenzae (species) [taxon 727], H1N1 subtype (serotype) [taxon 114727], Mycoplasmoides pneumoniae (Filterable agent of primary atypical pneumonia, species) [taxon 2104]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946129/full.md

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Source: https://tomesphere.com/paper/PMC12946129