# Participant perspectives on a multimodal program for neuropathic pain after spinal cord injury

**Authors:** Meredith Pinkerton, Roberta Vastano, Kim D. Anderson, Marlon Wong, Gabriel Fernandez, Eva Widerström-Noga

PMC · DOI: 10.3389/fpain.2026.1755081 · Frontiers in Pain Research · 2026-02-13

## TL;DR

A 12-week multimodal program for neuropathic pain after spinal cord injury reduced pain and improved participants' well-being, though some found effects short-lived.

## Contribution

This study introduces a novel multimodal program combining education, exercise, and walking illusions to address neuropathic pain after SCI.

## Key findings

- Participants reported reduced pain and pain interference after the program.
- Pain assessment scores showed significant reductions in neuropathic pain severity and impact.
- Some participants noted fatigue and minimal long-term pain relief.

## Abstract

Spinal cord injury (SCI) results in several medical consequences. While some of these are immediate, others, like chronic pain, may emerge after weeks or months. Roughly 60% of individuals develop persistent neuropathic pain within the first year after injury. Due to the limited efficacy and negative side-effects of current pharmacological agents, many patients seek non-pharmacological options.

The present mixed-method study explored individual perspectives of 35 participants with neuropathic pain and SCI on a multimodal 12-week pain program including pain education, exercise, and walking illusions.

After completion of the program participants reported reduced pain and pain interference, better understanding of pain and pain management, and lower medication use. Other reported benefits included an expanded mindset, useful community and interpersonal connections, positive health impact, increased motivation, and elevated self-image. Negative perceptions included fatigue, short-lasting or minimal effects on pain, and lack of realism of walking illusions. Pain assessment scores supported the overall positive effects on neuropathic pain with significant reductions in neuropathic pain severity, pain interference with activities and mood, and difficulty dealing with pain. These results suggest that a multimodal pain program combining pain education, exercise and walking illusions can reduce neuropathic pain and its impact after SCI.

## Linked entities

- **Diseases:** spinal cord injury (MONDO:0043797)

## Full-text entities

- **Genes:** MPI (mannose phosphate isomerase) [NCBI Gene 4351] {aka CDG1B, PMI, PMI1}
- **Diseases:** motion sickness (MESH:D009041), cancer (MESH:D009369), anxiety (MESH:D001007), inflammation (MESH:D007249), injury (MESH:D014947), Pain (MESH:D010146), convulsants (MESH:D012640), in body (MESH:D001835), SCI (MESH:D013119), Mood (MESH:D019964), fatigue (MESH:D005221), cardiovascular disease (MESH:D002318), neuronal hyperactivity (MESH:D001289), rheumatoid arthritis (MESH:D001172), Illusion of (MESH:D007088), multiple sclerosis (MESH:D009103), chronic pain (MESH:D059350), depression (MESH:D003866), Neuropathic Pain (MESH:D009437), dysesthesia (MESH:D010292)
- **Chemicals:** cholesterol (MESH:D002784), pregabalin (MESH:D000069583), gabapentin (MESH:D000077206), alcohol (MESH:D000438), amitriptyline (MESH:D000639)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12946072/full.md

## References

105 references — full list in the complete paper: https://tomesphere.com/paper/PMC12946072/full.md

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Source: https://tomesphere.com/paper/PMC12946072