# Linitis Plastica in a Patient With a BRCA2 Mutation: A Case Report

## TL;DR

A patient with a BRCA2 mutation developed a rare type of gastric cancer called linitis plastica, suggesting a possible link between BRCA2 mutations and gastric cancer.

## Contribution

This case report presents a rare instance of linitis plastica in a BRCA2 mutation carrier, highlighting a potential but understudied connection.

## Key findings

- A patient with a BRCA2 mutation was diagnosed with linitis plastica, a diffuse form of gastric cancer.
- The case suggests a possible association between BRCA2 mutations and gastric cancer that warrants further investigation.

## Abstract

BRCA2 pathogenic mutations are well-established risk factors for breast, ovarian, prostate, and pancreatic cancers. However, the relationship between BRCA2 mutations and gastric cancer (GC) remains understudied. This case involves a patient with a pathogenic BRCA2 mutation diagnosed with linitis plastica, a diffuse form of GC characterized by stiffening of the gastric lining, akin to a “leather bottle.” This case highlights the importance of further research to elucidate the connection between GC and BRCA2 mutations, which may lead to expanded surveillance guidelines for affected individuals. Clinicians should consider the potential elevated risk of GC in patients with BRCA2 mutations.