# Acceptability, Usability, and Clinical Integration of a Clinic-Based Digital Game for HPV Education: Qualitative Perspectives from Adolescents, Parents, and Healthcare Providers

**Authors:** Elizabeth Reifsnider, Satya Subedi, Nouran Ghonaim, Megan Whaley, Angela Chia-Chen Chen

PMC · DOI: 10.3390/vaccines14020116 · Vaccines · 2026-01-26

## TL;DR

A digital game called HPV Detective was found to be acceptable and usable for educating adolescents and parents about HPV during clinic visits.

## Contribution

The study introduces a clinic-based digital game as a novel tool for HPV education and examines its usability and clinical integration.

## Key findings

- Adolescents found the game intuitive and enjoyable with interactive challenges.
- Parents appreciated the clarity of HPV information and the game's ability to initiate health conversations.
- Healthcare providers saw the game as a feasible tool but noted challenges like parental hesitancy.

## Abstract

Background/Objectives: HPV vaccination is safe, effective, and recommended at ages 11–12, yet uptake remains suboptimal. Serious video games may offer an innovative strategy to deliver brief, engaging education during clinic visits. This qualitative paper, embedded within a mixed-methods study, examined adolescents’, parents’, and healthcare providers’ (HCPs’) perceptions of the acceptability, usability, and perceived clinical applicability of HPV Detective, a tablet-based digital game designed to provide HPV-related education to parent–child dyads during pediatric clinic wait times. Methods: Eight adolescent–parent dyads (N = 16) and three HCPs from university-affiliated pediatric clinics participated in 30–60-min semi-structured Zoom interviews. Interviews were audio-recorded, transcribed, and thematically analyzed by two coders, with discrepancies resolved by consensus and reviewed by a third researcher. Results: Participants identified five key dyadic themes and four HCP themes. Adolescents described the gameplay as intuitive and enjoyable, highlighting interactive challenges and realistic avatars. Parents valued the clarity of HPV information and noted that the game helped initiate health-related conversations. Both adolescents and parents suggested enhancements including voice narration and greater customization and agreed that the game was well suited for 10–15-min clinic wait times, with text messaging preferred for follow-up. HCPs emphasized challenges such as parental hesitancy and competing clinical demands and viewed the game as a feasible adjunct to support vaccine-related discussions. Conclusions: Findings suggest the acceptability, usability, and perceived clinical applicability of a brief, clinic-based digital game for HPV-related education and engagement among adolescents and their parents.

## Full-text entities

- **Genes:** PTPN6 (protein tyrosine phosphatase non-receptor type 6) [NCBI Gene 5777] {aka HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1}, CYCSP51 (CYCS pseudogene 51) [NCBI Gene 343045] {aka HCP1}
- **Diseases:** sexually transmitted infection (MESH:D012749), preterm birth (MESH:D047928), cancer (MESH:D009369), diabetes (MESH:D003920), COVID-19 (MESH:D000086382), cervical, oropharyngeal, and other anogenital cancers (MESH:D009959), asthma (MESH:D001249), ear infections (MESH:D010031), injury to (MESH:D014947), flu (MESH:D007251), HPV infections (MESH:D030361), rashes (MESH:D005076), strep throat (MESH:D013290), common colds (MESH:D003139)
- **Chemicals:** Avatar (-)
- **Species:** Human papillomavirus (species) [taxon 10566], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

31 references — full list in the complete paper: https://tomesphere.com/paper/PMC12945110/full.md

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Source: https://tomesphere.com/paper/PMC12945110