# Toxin–Host Interaction of Clostridium Toxins

**Authors:** Jonatan Dorca-Arévalo

PMC · DOI: 10.3390/toxins18020067 · Toxins · 2026-01-27

## Full-text entities

- **Genes:** SRSF1 (serine and arginine rich splicing factor 1) [NCBI Gene 6426] {aka ASF, NEDFBA, SF2, SF2p33, SFRS1, SRp30a}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, SRPK1 (SRSF protein kinase 1) [NCBI Gene 6732] {aka SFRSK1}, SF3B2 (splicing factor 3b subunit 2) [NCBI Gene 10992] {aka CFM, Cus1, HFM, SAP145, SF3B145, SF3b1}, THOC2 (THO complex subunit 2) [NCBI Gene 57187] {aka AMC7, CXorf3, MRX12, MRX35, THO2, XLID12}, MAL (mal, T cell differentiation protein (MAL blood group)) [NCBI Gene 4118] {aka HLD28, MVP17, VIP17}
- **Diseases:** Clostridioides difficile (MESH:D003015), death (MESH:D003643), infections (MESH:D007239), gastrointestinal disorders (MESH:D005767), cytotoxic (MESH:D064420), multiple sclerosis (MESH:D009103), injury to (MESH:D014947), gas gangrene (MESH:D005738), pseudomembranous colitis (MESH:D004761), neurotoxicity (MESH:D020258), edema (MESH:D004487), diarrhea (MESH:D003967), enterotoxemia (MESH:D004767)
- **Chemicals:** aluminum-adjuvant (-), TcdB (MESH:C057908), DDAB (MESH:C015831), Domperidone (MESH:D004294), PLGA (MESH:D000077182), VER-155008 (MESH:C550733)
- **Species:** Homo sapiens (human, species) [taxon 9606], Clostridioides difficile (species) [taxon 1496], Clostridium perfringens (species) [taxon 1502], Clostridium botulinum (species) [taxon 1491], Mus musculus (house mouse, species) [taxon 10090], Clostridium tetani (species) [taxon 1513]
- **Cell lines:** MDCK — Canis lupus familiaris (Dog), Spontaneously immortalized cell line (CVCL_0422), FRT — Rattus norvegicus (Rat), Spontaneously immortalized cell line (CVCL_A6IE), HeLa — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0030), 1G11 — Mus musculus (Mouse), Hybridoma (CVCL_B0E9), MOLT4 — Homo sapiens (Human), Adult T acute lymphoblastic leukemia, Cancer cell line (CVCL_0013)

## Full text

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12945007/full.md

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Source: https://tomesphere.com/paper/PMC12945007