# Unbiased Sequencing Identifies Batai Virus as an Emerging Orthobunyavirus in Hungarian Cattle

**Authors:** Zalán G. Homonnay, Renáta Varga-Kugler, István Kiss

PMC · DOI: 10.3390/v18020194 · Viruses · 2026-02-01

## TL;DR

Batai virus, an emerging Orthobunyavirus, was unexpectedly found in Hungarian cattle using unbiased sequencing, highlighting the need for improved surveillance.

## Contribution

The first identification of Batai virus in Hungarian cattle using unbiased sequencing during routine BVDV surveillance.

## Key findings

- Batai virus was detected in cattle during routine BVDV surveillance using next-generation sequencing.
- The detection underscores the importance of unbiased sequencing in identifying emerging pathogens.
- The virus's presence in livestock highlights the need for integrated surveillance at the human–animal–environment interface.

## Abstract

This case report describes the unexpected identification and genomic characterization of Batai virus (BATV), an Orthobunyavirus, during routine bovine viral diarrhea virus (BVDV) surveillance on a cattle farm in Hungary. The discovery was facilitated by next-generation sequencing (NGS) technologies and highlights the importance of unbiased sequencing in pathogen surveillance. Although BATV currently exhibits limited zoonotic impact, its detection in livestock underscore the critical need for integrated surveillance at the human–animal–environment interface and the adoption of proper diagnostic tools to identify potential threats before they escalate.

## Linked entities

- **Species:** Bos taurus (taxon 9913)

## Full-text entities

- **Genes:** CPE (carboxypeptidase E) [NCBI Gene 1363] {aka BDVS, CPH, IDDHH}
- **Diseases:** reproductive failure (MESH:D051437), mucosal disease (MESH:D004194), injury to (MESH:D014947), respiratory illness (MESH:D012140), flu (MESH:D007251), reproductive disorders (MESH:D060737), neurologic symptoms (MESH:D009461), febrile illness (MESH:D005334), diarrhea (MESH:D003967), infected (MESH:D007239), encephalitis (MESH:D004660), CP (MESH:D002972), abortions (MESH:D000026), birth defects (MESH:D000014), BATV (MESH:D014777), malaria (MESH:D008288), BVDV (MESH:D001912)
- **Chemicals:** Glycopreotein (-), CO2 (MESH:D002245)
- **Species:** Anopheles (series) [taxon 44484], Sus scrofa (pig, species) [taxon 9823], Coquillettidia richiardii (species) [taxon 1245328], Chironomus thummi (midge, species) [taxon 7154], Ovis aries (domestic sheep, species) [taxon 9940], Batai virus (no rank) [taxon 80942], Bunyamwera virus (no rank) [taxon 35304], Bovine viral diarrhea virus 1 (no rank) [taxon 11099], Homo sapiens (human, species) [taxon 9606], Aedes (subgenus) [taxon 149531], Phoca vitulina (harbor seal, species) [taxon 9720], Bovine viral diarrhea virus 2 (no rank) [taxon 54315], Porcine circovirus 2 (no rank) [taxon 85708], Capra hircus (domestic goat, species) [taxon 9925], Orthopestivirus (genus) [taxon 11095], Bos taurus (bovine, species) [taxon 9913], Equus caballus (domestic horse, species) [taxon 9796]

## Full text

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## Figures

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12944998/full.md

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Source: https://tomesphere.com/paper/PMC12944998