A Hierarchical Microglial-Targeting Nanoplatform for the Therapy of Parkinson’s Disease by Modulating Mitochondrial Dysfunction
Yue Xing, Shumeng Liu, Yue Na, Hao Wu, Chi Liu, Bohan Zhang, Zhigang Wang, Xiuhong Wu, Ning Zhang, Fang Geng
TL;DR
A new nanoplatform targets microglia in Parkinson’s Disease to repair mitochondrial dysfunction and reduce inflammation.
Contribution
A dual-targeting nanosystem was designed to deliver wedelolactone to microglia for PD therapy.
Findings
The nano-delivery system increased blood half-life and brain distribution by evading immune clearance.
It specifically targeted microglia, repaired mitochondrial structure, and reduced pro-inflammatory cytokines.
The system improved the inflammatory microenvironment in PD mouse models.
Abstract
Background: Mitochondrial dysfunction in microglia is an important pathogenic factor inducing the onset of Parkinson’s Disease (PD). To address this challenge, a novel hierarchical nano-delivery system was developed to deliver a PD therapeutic agent, wedelolactone (WED) to modulate mitochondrial dysfunction. Methods: The nano-delivery system (WED@RBCm-B6&RAP12-NPs) was coated with red blood membrane (RBCm) to avoid immune clearance and conjugated with the BBB-penetrating peptide CGHKAKGPRK (B6) and the microglia targeting peptide EAKIEKHNHYQK (RAP12). Results: The experimental results demonstrated that this novel nano-delivery system could increase its half-life in blood circulation effectively via evading immune recognition and clearance and enhanced its brain distribution by synergistic effect of B6 and RAP12. By specifically targeting microglia in PD mouse brain, the system increased…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsParkinson's Disease Mechanisms and Treatments · Medicinal Plants and Neuroprotection · Alzheimer's disease research and treatments