# Development of Physiologically Based Pharmacokinetic (PBPK) Modeling

**Authors:** Bárbara Sánchez-Dengra, Isabel González-Álvarez

PMC · DOI: 10.3390/pharmaceutics18020238 · 2026-02-13

## Full-text entities

- **Genes:** CYP3A4 (cytochrome P450 family 3 subfamily A member 4) [NCBI Gene 1576] {aka CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4}, CYP2C9 (cytochrome P450 family 2 subfamily C member 9) [NCBI Gene 1559] {aka CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9}, GUSB (glucuronidase beta) [NCBI Gene 2990] {aka BG, MPS7}, UGT1A (UDP glucuronosyltransferase family 1 member A complex locus) [NCBI Gene 7361] {aka GNT1, UGT, UGT1, UGT1A@}
- **Diseases:** Colorectal Cancer (MESH:D015179), toxicity (MESH:D064420), obesity (MESH:D009765), injury to (MESH:D014947), renal and hepatic insufficiency (MESH:D048550), critically ill (MESH:D016638), tumor (MESH:D009369)
- **Chemicals:** Adapalene (MESH:D000068816), Lamotrigine (MESH:D000077213), leucovorin (MESH:D002955), Genistein (MESH:D019833), Meropenem (MESH:D000077731), 5-fluorouracil (MESH:D005472), Efavirenz (MESH:C098320), oxaliplatin (MESH:D000077150), TCB (MESH:C513573), Glucuronide (MESH:D020719), irinotecan (MESH:D000077146)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

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Source: https://tomesphere.com/paper/PMC12944453