Transforming Cancer Care with Oncosomes: Insight into Biogenesis, Functional Role, and Therapeutic Potential
Popat Mohite, Rajesh Bogati, Aishwarya Gorad, Abhijeet Puri, Sudarshan Singh, Chuda Chittasupho
TL;DR
Oncosomes, large vesicles from tumor cells, show promise for targeted drug delivery in cancer but face challenges in manufacturing and regulation.
Contribution
This review provides a comprehensive analysis of oncosome biogenesis, therapeutic potential, and current technical barriers.
Findings
Oncosomes can carry oncogenic proteins, nucleic acids, and lipids for tumor communication and drug delivery.
Current methods for oncosome isolation and cargo loading include incubation, electroporation, and sonication.
Challenges include heterogeneity, low loading efficiency, and regulatory uncertainty for clinical translation.
Abstract
Oncosomes, a distinct subclass of extracellular vesicles released predominantly by tumor cells, have attracted increasing interest as potential carriers for targeted drug delivery in cancer research. Characterized by their large size (1–10 µm) and complex molecular cargo, including oncogenic proteins, nucleic acids, and lipids, oncosomes provide a biologically relevant platform for investigating tumor-associated communication and cargo transport. Preclinical studies suggest that oncosomes may enable tumor-associated delivery of therapeutic agents; however, evidence to date remains largely proof-of-concept and derived from in vitro and animal models. This review summarizes current knowledge on oncosome biogenesis and molecular composition; discusses their roles in cancer progression and metastasis; and critically evaluates existing methodologies for oncosome isolation, characterization,…
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Taxonomy
TopicsExtracellular vesicles in disease · Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery