# Silver Nanoparticles as Anticancer Agents: Mechanisms Insight, Current Studies, and Limitations

## TL;DR

This review explores how silver nanoparticles can fight cancer by causing cell damage and death, but also highlights challenges like toxicity and the need for better targeting.

## Contribution

The paper provides a comprehensive overview of AgNPs' anticancer mechanisms and limitations, emphasizing recent advancements and strategies for clinical translation.

## Key findings

- AgNPs induce anticancer effects through oxidative stress, DNA damage, and apoptosis.
- Green-synthesized AgNPs show improved biocompatibility and selective toxicity to cancer cells.
- Strategies like surface functionalization and combination therapies are proposed to enhance efficacy and reduce toxicity.

## Abstract

Silver nanoparticles (AgNPs) have been studied extensively in recent years due to their biological activities. In addition to their well-known antibacterial, antioxidant, and anti-inflammatory properties, AgNPs also exhibit anticancer properties. Increasing evidence from in vivo and in vitro studies demonstrates that AgNPs exert significant anticancer effects through multiple mechanisms, including oxidative stress, mitochondrial dysfunction, DNA damage, cell cycle arrest, and apoptosis. In addition to these mechanisms, inhibition of certain pathways is also an important mechanism that enables AgNPs to exhibit anticancer activity. Furthermore, green-synthesized AgNPs often exhibit enhanced biocompatibility and improved selective cytotoxicity against cancer cells. Despite these promising findings, concerns regarding AgNP-associated toxicity, non-specific cellular damage, and long-term safety remain major challenges limiting their clinical translation. Strategies such as size and shape optimization, surface functionalization, and combination therapies have been recommended to enhance anticancer efficacy while minimizing adverse effects on healthy cells. This review brings together recent studies, offers a broad perspective, and aims to present an objective viewpoint to fully explain the anticancer potential and current challenges of AgNPs.