Construction of Multifunctional Fe3O4@MSN@PDA-HA-FA Nanocarriers and Research on Synergistic Tumor Therapy
Lijie Liu, Yunxia Hu, Xinyuan Zhang, Guoying Huang, Xiayu Liang, Shige Wang, Lei Tian, Chengzheng Jia
TL;DR
Researchers created a multifunctional nanoparticle that combines photothermal and chemodynamic therapies to improve cancer treatment effectiveness.
Contribution
A novel Fe3O4@MSN@PDA-HA-FA nanocarrier is developed for synergistic tumor therapy combining PTT, CDT, and chemotherapy.
Findings
The nanocarrier shows high photothermal conversion and heat transfer efficiency under near-infrared light.
It enhances hydroxyl radical generation via Fenton reaction for chemodynamic therapy.
In vitro experiments confirm the synergistic antitumor efficacy of combined therapies.
Abstract
Background: Chemodynamic therapy (CDT) and photothermal therapy (PTT) based on nanomaterials have garnered widespread attention in cancer treatment. However, most single-modal nanotherapeutics suffer from limited therapeutic efficacy. Methods: Herein, a magnetic mesoporous composite nanoparticle, Fe3O4@MSN@PDA-HA-FA, is successfully fabricated, with Fe3O4 nanoparticles as the magnetic core; mesoporous silica nanoparticles (MSNs) as the mesoporous shell; and dopamine hydrochloride (DA·HCl), hyaluronic acid (HA), and folic acid (FA) as the functional ligands. Results: Notably, this composite serves as both an efficient photothermal converter and a chemodynamic promoter, enhancing hydroxyl radical (·OH) generation and improving PTT efficacy. Under near-infrared (NIR) light irradiation, Fe3O4@MSN@PDA-HA-FA exhibits high photothermal conversion and heat transfer efficiencies. The Fe2+ ions…
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Taxonomy
TopicsNanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis