# Metal and Metal Oxide Nanoparticles Using Artemisia Species: Synthesis, Characterization and Applications

**Authors:** Delia Luca, Roxana Jijie, Gabriela Vochita, Lucia-Florina Popovici, Marius-Nicusor Grigore, Lacramioara Oprica

PMC · DOI: 10.3390/plants15040600 · 2026-02-13

## TL;DR

This review explores using Artemisia plants to create metal nanoparticles with potential uses in medicine, agriculture, and environmental cleanup.

## Contribution

The paper systematically reviews green synthesis methods and applications of metal nanoparticles using Artemisia species.

## Key findings

- Artemisia extracts can synthesize metal nanoparticles with controlled size and morphology.
- The nanoparticles show antimicrobial, antioxidant, and anticancer properties.
- They have potential in agriculture and environmental remediation.

## Abstract

This review aims to explore the green synthesis of metal and metal oxide nanoparticles using various species of the genus Artemisia. The synthesis processes commonly involve aqueous or organic extracts of plant parts (e.g., leaves, stems, and roots), which react with metal salt solutions (e.g., AgNO3, Zn(NO3)2, HAuCl4, Cu(NO3)2) under controlled parameters, including pH, temperature, and light exposure. The synthesized nanoparticles are characterized using techniques such as UV–Visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), and zeta potential analysis. These approaches provide information on nanoparticle size, morphology, crystallinity, surface chemistry and charge, which are significantly influenced by synthesis parameters and the specific Artemisia species used. The biosynthesized nanoparticles have demonstrated promising multifunctional applications, including broad-spectrum antimicrobial activity against bacterial and fungal strains, antioxidant capacity, anticancer potential, as well as applications in agriculture and environmental remediation.

## Linked entities

- **Chemicals:** AgNO3 (PubChem CID 24470), Zn(NO3)2 (PubChem CID 24518), HAuCl4 (PubChem CID 10925836), Cu(NO3)2 (PubChem CID 18616)
- **Species:** Artemisia (taxon 4219)

## Full-text entities

- **Genes:** BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 581] {aka BCL2L4}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, CASP9 (caspase 9) [NCBI Gene 842] {aka APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56}, CASP3 (caspase 3) [NCBI Gene 836] {aka CPP32, CPP32B, SCA-1}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, CAT (catalase) [NCBI Gene 847], PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, H3P16 (H3 histone pseudogene 16) [NCBI Gene 644914] {aka H3.6, H3F3AP6, p21}
- **Diseases:** injury to (MESH:D014947), cancer (MESH:D009369), gastric cancer (MESH:D013274), lung adenocarcinoma (MESH:D000077192), colon cancer (MESH:D015179), Phytophthora infection (MESH:D007239), cytotoxic (MESH:D064420), breast adenocarcinoma (MESH:D001943), ovarian cancer (MESH:D010051), liver cancer (MESH:D006528)
- **Chemicals:** proline (MESH:D011392), silver oxide (MESH:C040225), methanol (MESH:D000432), gold (MESH:D006046), COO (MESH:C041069), zinc acetate (MESH:D019345), Metal (MESH:D008670), Zn (MESH:D015032), O (MESH:D010100), salt (MESH:D012492), HAuCl4 (MESH:C024568), carboxylic acids (MESH:D002264), tin oxide (MESH:C045358), DPPH (MESH:C004931), AgNO3 (MESH:D012835), ester (MESH:D004952), FeCl3 (MESH:C024555), MB (MESH:D008751), 4-aminophenol (MESH:C026729), ZnO (MESH:D015034), amide (MESH:D000577), nitro compounds (MESH:D009574), water (MESH:D014867), phenol (MESH:D019800), essential oil (MESH:D009822), terpenoids (MESH:D013729), alkene (MESH:D000475), FE (MESH:D007501), phenolic acids (MESH:C017616), alkaloids (MESH:D000470), ascorbic acid (MESH:D001205), Cu (MESH:D003300), iron oxide (MESH:C000499), copper nitrate (MESH:C516433), Ag (MESH:D012834), ethanol (MESH:D000431), CuO (MESH:C030973), cisplatin (MESH:D002945), A. deserti extract (-), thiol (MESH:D013438), malondialdehyde (MESH:D008315), selenium (MESH:D012643), 4-nitrophenol (MESH:C024836), phenols (MESH:D010636), titanium dioxide (MESH:C009495), sterols (MESH:D013261), ABTS (MESH:C002502), Alcohols (MESH:D000438), MO (MESH:C100258), Zn(NO3)2 (MESH:C042103), coumarins (MESH:D003374), manganese (MESH:D008345), Ether (MESH:D004986), flavonoids (MESH:D005419)
- **Species:** Candida albicans (species) [taxon 5476], Artemisia turcomanica (species) [taxon 1338419], Aspergillus fumigatus (species) [taxon 746128], Streptococcus mutans (species) [taxon 1309], Artemisia herba-alba (white wormwood, species) [taxon 72329], Bacillus cereus (species) [taxon 1396], Escherichia coli (E. coli, species) [taxon 562], Phytophthora (genus) [taxon 4783], Bacillus subtilis (species) [taxon 1423], Pseudomonas aeruginosa (species) [taxon 287], Artemisia absinthium (species) [taxon 72332], Klebsiella pneumoniae (species) [taxon 573], Artemisia capillaris (species) [taxon 265783], Artemisia tilesii (Aleutian mugwort, species) [taxon 200866], Ocimum basilicum (basil, species) [taxon 39350], Artemisia annua (sweet Annie, species) [taxon 35608], Acinetobacter johnsonii (species) [taxon 40214], A. indica [taxon 316126], Artemisia schrenkiana (species) [taxon 669139], Vigna radiata (mung bean, species) [taxon 157791], Cronobacter sakazakii (species) [taxon 28141], Artemisia kopetdaghensis (species) [taxon 1338416], A. flavus [taxon 315677], Artemisia abrotanum (species) [taxon 86306], Aspergillus flavus (species) [taxon 5059], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Staphylococcus aureus (species) [taxon 1280], Enterobacter cloacae (species) [taxon 550], Homo sapiens (human, species) [taxon 9606], A. salina [taxon 400392], Dianthus caryophyllus (carnation, species) [taxon 3570], Artemisia oliveriana (species) [taxon 1338417], Artemisia stelleriana (oldwoman, species) [taxon 333954], Artemisia (genus) [taxon 4219]
- **Cell lines:** HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027), L-929 — Mus musculus (Mouse), Spontaneously immortalized cell line (CVCL_AR58), A549 — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_0023), HFF — Homo sapiens (Human), Finite cell line (CVCL_XB54), AGS — Homo sapiens (Human), Gastric adenocarcinoma, Cancer cell line (CVCL_0139), MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031), A2780-CP — Homo sapiens (Human), Ovarian endometrioid adenocarcinoma, Cancer cell line (CVCL_0135), A431 — Homo sapiens (Human), Skin squamous cell carcinoma, Cancer cell line (CVCL_0037), HaCaT — Homo sapiens (Human), Spontaneously immortalized cell line (CVCL_0038), HEK293 — Homo sapiens (Human), Transformed cell line (CVCL_0045), A375 — Homo sapiens (Human), Amelanotic melanoma, Cancer cell line (CVCL_0132), HT-29 — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0320), A2780 — Homo sapiens (Human), Ovarian endometrioid adenocarcinoma, Cancer cell line (CVCL_0134), HeLa — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_0030)

## Figures

22 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12944093/full.md

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Source: https://tomesphere.com/paper/PMC12944093