UV-Crosslinking Effects on the Physicochemical and Rheological Properties of Fish Collagen Ink for 3D Bioprinting
Zahra Rajabimashhadi, Nunzia Gallo, Francesca Russo, Luca Salvatore, Sonia Bagheri, Claudio Mele, Alessandro Sannino, Carola Esposito Corcione, Francesca Lionetto
TL;DR
This paper explores using UV-crosslinked fish collagen as a safer bioink for 3D bioprinting, improving its stability and suitability for tissue engineering.
Contribution
The study introduces UV-crosslinked fish collagen as a novel, sustainable bioink with enhanced structural properties for 3D bioprinting.
Findings
UV crosslinking significantly improved the structural integrity and stability of printed fish collagen scaffolds.
UV treatment enhanced thermal behavior, degradation resistance, and surface roughness of the bioink.
Abstract
Three-dimensional bioprinting revolutionized tissue and organ replacement by enabling the precise deposition of living cells and biomaterials, making it ideal for biomedical applications. Natural polymers are commonly used as bioink for their biocompatibility and bioactivity. Among them, type I collagen, the most abundant protein of extracellular matrix, is commonly used as bioink. However, mammalian-derived collagens raise concerns related to zoonotic disease transmission, religious restrictions, and immunogenicity. Fish-derived collagen represents a safer and more sustainable alternative, although its rapid degradation and limited mechanical properties remain significant challenges. In this study, the printability of a novel fish collagen ink was assessed for micropatterned scaffolding by extrusion. In order to overcome material-related challenges, the effect of UV-induced…
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Taxonomy
TopicsCollagen: Extraction and Characterization · 3D Printing in Biomedical Research · Marine Biology and Environmental Chemistry