# Camphor’s Therapeutic Uses and Potential Hazards: An In-Depth Review of Its Medicinal Applications

**Authors:** Anam Shabbir, Mazeyar Parvinzadeh Gashti

PMC · DOI: 10.3390/molecules31040648 · 2026-02-13

## TL;DR

This paper reviews camphor's historical and modern medicinal uses, highlighting its potential in treating diseases like cancer and diabetes.

## Contribution

The paper provides new insights into camphor's therapeutic potential and integrates recent research up to 2025.

## Key findings

- Camphor exhibits a range of biological activities including antimicrobial and anticancer effects.
- The review emphasizes camphor's role in integrating traditional knowledge with modern medicine.
- Camphor is highlighted as a sustainable and effective plant-based compound for healthcare.

## Abstract

Natural products have long been integral to traditional medicine, offering diverse therapeutic benefits. Increasing concerns about the side effects of synthetic drugs have heightened interest in plant-derived compounds. The camphor tree (Cinnamomum camphora (L.) J. Presl) and its derivatives, such as camphor oil, have been valued for centuries. Historically, C. camphora was used as a fumigant during the Black Death, a prized ingredient in perfumes, and a key component in embalming fluids. Today, camphor extracted from C. camphora is widely used as a fragrance in cosmetics, a flavoring agent in food, an ingredient in household cleaners, and a topical remedy for minor muscle pain. Camphor is primarily obtained through steam distillation of the wood but can also be synthetically produced from turpentine. Camphor exhibits a broad spectrum of biological activities, including insecticidal, antimicrobial, antiviral, anticoccidial, antinociceptive, anticancer, and antitussive effects, and has historically been employed to alleviate inflammation, congestion, pain, and irritation. This review integrates recently published research (up to 2025) on the biological activities and therapeutic applications of camphor that were not comprehensively addressed in earlier reviews. Furthermore, a mechanistic perspective is provided on camphor’s pharmacological effects, including its antibacterial, antimicrobial, antiviral, and anticancer actions, highlighting the chemical basis underlying these activities. This review provides a comprehensive overview of the history, applications, and biological properties of camphor, emphasizing its potential in preventing and treating serious diseases such as cancer and diabetes. In addition, sustainability and translational relevance are emphasized, demonstrating how camphor exemplifies the integration of traditional knowledge with contemporary medicinal research. Overall, this review offers new insights into the therapeutic potential of camphor, underscoring its promising role in addressing major medical challenges while supporting the growing importance of plant-based compounds in modern healthcare due to their effectiveness, safety, and sustainability.

## Linked entities

- **Chemicals:** camphor (PubChem CID 2537)
- **Diseases:** cancer (MONDO:0004992), diabetes (MONDO:0005015)

## Full-text entities

- **Diseases:** nervous tension (MESH:D018781), injuries (MESH:D014947), Neurodegenerative Disorders (MESH:D019636), circulatory collapse (MESH:D012769), respiratory tract infections (MESH:D012141), anti-inflammatory (MESH:D007249), pain (MESH:D010146), influenza (MESH:D007251), Parkinson's disease (MESH:D010300), skin irritations (MESH:D012871), irritation (MESH:D001523), Alzheimer's disease (MESH:D000544), liver or kidney disorders (MESH:D051437), neurotoxicity (MESH:D020258), poisoning (MESH:D011041), diabetes (MESH:D003920), Cancer (MESH:D009369), vascular insufficiency (MESH:D065666), anthrax (MESH:D000881), autism (MESH:D001321), edema (MESH:D004487), central nervous system toxicity (MESH:D002493), anxiety (MESH:D001007), respiratory ailments (MESH:D012131), stress-related disorders (MESH:D000068099), cholera (MESH:D002771), nausea (MESH:D009325), arrhythmias (MESH:D001145), dengue (MESH:D003715), throat discomfort (MESH:C538390), tachycardia (MESH:D013610), Musculoskeletal Pain (MESH:D059352), microbial infections (MESH:D015163), stroke (MESH:D020521), diarrhea (MESH:D003967), sprains (MESH:D013180), confusion (MESH:D003221), neurological disorders (MESH:D009461), convulsions (MESH:D012640), cardiac distress (MESH:D012128), fever (MESH:D005334), toothaches (MESH:D014098), vomiting (MESH:D014839), collapse (MESH:D001261), arthritis (MESH:D001168), muscle spasms (MESH:D013035), dysentery (MESH:D004403), epilepsy (MESH:D004827), stiffness (MESH:C566112), oral disorders (MESH:D009056), brain complications (MESH:D001927), Death (MESH:D003643), involuntary contractions (MESH:D014202), tonic-clonic convulsions (MESH:D004830), cardiovascular complications (MESH:D002318), bronchitis (MESH:D001991), gastrointestinal discomforts (MESH:D005767), bad breath (MESH:D012120), cough (MESH:D003371), numb (MESH:D006987)
- **Chemicals:** camphene (MESH:C019286), MVA (MESH:D008798), 1,8-cineole (MESH:D000077591), salicylic acid (MESH:D020156), oxygen (MESH:D010100), alpha-terpineol (MESH:C016775), paclitaxel (MESH:D017239), dipentene (MESH:D000077222), menthol (MESH:D008610), methyl salicylate (MESH:C033069), carbon (MESH:D002244), polymer (MESH:D011108), aspirin (MESH:D001241), water (MESH:D014867), alpha-pinene (MESH:C005451), sesame oil (MESH:D012715), GPP (MESH:C511282), Essential oils (MESH:D009822), gamma-terpinene (MESH:C018669), Terpenes (MESH:D013729), beta-phellandrene (MESH:C058582), alpha-humulene (MESH:C042686), acetic acid (MESH:D019342), beta-selinene (MESH:C087920), beta-pinene (MESH:C010789), germacrene D (MESH:C027259), terpinen-4-ol (MESH:C034019), (+)-borneol (MESH:C022871), ozone (MESH:D010126), 1,7,7-trimethylbicyclo [2.2.1]-2-heptanone (-), olive oil (MESH:D000069463), isobornyl acetate (MESH:C011331), Linalool (MESH:C018584), beta-caryophyllene (MESH:C024714), hydroxylamine-O-sulfonic acid (MESH:C008042), C10H16O. (MESH:D002164), penicillin (MESH:D010406), glucuronic acid (MESH:D020723), artemisia ketone (MESH:C494252), beta-myrcene (MESH:C008574), geranyl pyrophosphate (MESH:C015234), sabinene (MESH:C035127), oil (MESH:D009821), monoterpenes (MESH:D039821), turpentine (MESH:D014425), citric acid (MESH:D019343), chloroform (MESH:D002725), lipid (MESH:D008055), safrole (MESH:D012451), sesquiterpenes (MESH:D012717), OPP (MESH:C402885), acetate (MESH:D000085), diphosphate (MESH:D011756), alcohol (MESH:D000438), ether (MESH:D004986), eugenol (MESH:D005054), 3-methyl-2-butenoic acid (MESH:C011546)
- **Species:** Salvia officinalis (garden sage, species) [taxon 38868], Cinnamomum camphora (camphor tree, species) [taxon 13429], Olea europaea (common olive, species) [taxon 4146], Candida albicans (species) [taxon 5476], Juniperus (junipers, genus) [taxon 13100], Lavandula angustifolia (lavender, species) [taxon 39329], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932], Culex quinquefasciatus (southern house mosquito, species) [taxon 7176], Ocimum basilicum (basil, species) [taxon 39350], Artemisia annua (sweet Annie, species) [taxon 35608], Enterococcus hirae (species) [taxon 1354], Salvia rosmarinus (rosemary, species) [taxon 39367], Thuja occidentalis (species) [taxon 3317], Thuja (genus) [taxon 3315], Cupressus (cypress, genus) [taxon 13468], Anopheles culicifacies (species) [taxon 139723], Dracocephalum officinale (hyssop, species) [taxon 39324], Rattus norvegicus (brown rat, species) [taxon 10116], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606], Anopheles gambiae (African malaria mosquito, species) [taxon 7165], Cavia porcellus (domestic guinea pig, species) [taxon 10141], Anopheles funestus (African malaria mosquito, species) [taxon 62324], Lasioderma serricorne (cigarette beetle, species) [taxon 295660]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12943631/full.md

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Source: https://tomesphere.com/paper/PMC12943631