# Almond Supplementation Improves Acne Lesions and Skin Microbial Diversity in Adults with Mild to Moderate Acne Vulgaris

**Authors:** Panchali Moitra, Jagmeet Madan, Krisha Shah, Pradnya Mandavkar, Rajiv Joshi, Soumik Kalita, Shobha A. Udipi

PMC · DOI: 10.3390/nu18040625 · 2026-02-13

## TL;DR

Eating almonds daily for 20 weeks reduced acne lesions and improved skin microbial diversity in adults with mild to moderate acne.

## Contribution

This study demonstrates almond supplementation as a novel dietary intervention for acne and skin microbiome health.

## Key findings

- Almond group showed greater reductions in total, inflammatory, and non-inflammatory acne lesion counts compared to controls.
- Almond consumption increased skin microbial diversity as measured by Shannon and Chao1 indices.
- Almond group experienced significant improvements in acne-related quality of life and anxiety symptoms.

## Abstract

Objectives: This randomized, controlled, parallel-group study was conducted to evaluate the effectiveness of daily almond consumption on acne lesion counts, skin hydration, sebum production, and skin microflora composition in 18–35-year-old young adults with acne vulgaris in Mumbai, India. Methods: A defined amount of whole, unsalted almonds with skin (60 g) was provided to the experimental group (n = 36). The control group (n = 38) received isocaloric cereal-pulse-based snack varieties. The primary endpoints were changes in inflammatory, non-inflammatory, and total acne lesion counts after 20 weeks of supplementation. Secondary endpoints included changes in facial sebum, hydration levels, skin morphology and microflora, and selected biochemical parameters. Results: At week 20, the almond group showed greater reductions in total lesion counts (−22.2% vs. −9.8%), inflammatory lesion counts (−8.3% vs. +12%), and non-inflammatory lesion counts (−26.1% vs. −20.4%) than controls. Objective lesion volume, area, and height measures for both single and clustered acne decreased in the almond group (p ≤ 0.001). Microbial diversity increased, with the Shannon index (2.6 to 3.4 (p = 0.039) and the Chao1 richness index (266.9 → 835.2; p < 0.001) showing improvements at endline. Moreover, significant post-intervention changes in the psychosocial outcomes, such as the acne-related quality of life scores (p < 0.001) and anxiety symptoms (p = 0.016), were observed in the almond group. Conclusions: Daily almond consumption reduced acne lesion count and improved skin microbial diversity and acne-specific quality of life, highlighting its potential to complement standard acne treatments and support skin health.

## Linked entities

- **Diseases:** acne vulgaris (MONDO:0011438)

## Full-text entities

- **Diseases:** papules (MESH:D000169), lesion (MESH:D009059), anxiety symptoms (MESH:D001008), Acne (MESH:D000152), obstruction (MESH:D000402), inflammatory skin condition (MESH:D012871), nut allergy (MESH:D021184), Generalized Anxiety Disorder (MESH:C000726808), cardiometabolic diseases (MESH:D024821), Inflammatory (MESH:D007249), injury to (MESH:D014947), Anxiety (MESH:D001007), Dysbiosis (MESH:D064806)
- **Chemicals:** lipid (MESH:D008055), isotretinoin (MESH:D015474), polyphenol (MESH:D059808), glycemia (MESH:D001786), short-chain fatty acid (MESH:D005232), magnesium (MESH:D008274), cholesterol (MESH:D002784), glucose (MESH:D005947), tryptophan (MESH:D014364), zinc (MESH:D015032), sugar (MESH:D000073893), melatonin (MESH:D008550), free (-), fatty acid (MESH:D005227), monounsaturated fatty acids (MESH:D005229), triglycerides (MESH:D014280), vitamin E (MESH:D014810), cortisol (MESH:D006854)
- **Species:** gut metagenome (species) [taxon 749906], Cutibacterium acnes (species) [taxon 1747], Homo sapiens (human, species) [taxon 9606], Lactobacillus (genus) [taxon 1578], Bifidobacterium (genus) [taxon 1678]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12943583/full.md

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Source: https://tomesphere.com/paper/PMC12943583