# Chinese Expert Consensus for the Application of rh-aFGF for Chronic Refractory Wounds

## TL;DR

This paper presents a Chinese expert consensus on using rh-aFGF to treat chronic wounds, offering guidelines to improve clinical outcomes and standardize its application.

## Contribution

The paper introduces 12 evidence-based expert recommendations for rh-aFGF use in chronic refractory wounds.

## Key findings

- Twelve clinical application recommendations for rh-aFGF were developed, including treatment duration and dosage.
- Seven strong, four moderate, and one weak recommendation were identified for different clinical scenarios.
- The consensus supports rh-aFGF's clinical value and guides its combination with other wound care products.

## Abstract

Background and Objective: Chronic refractory wounds not only persist and delay healing, causing physical and mental suffering to patients and reducing their quality of life but also impose a heavy burden on their families and society. Recombinant human acidic fibroblast growth factor (rh-aFGF), approved in China for decades, is a growth factor with multiple biological effects which can promote the healing of various wounds. It is crucial to develop an rh-aFGF expert consensus for standardizing the clinical application of aFGF and enhancing its clinical value. Methods: The literature related to rh-aFGF, including clinical trials, experimental research, and reviews, was collected and selected from PubMed, Web of Science, Medline, CNKI, and the Wangfang database. The expert recommendations were formed by a combination of clinical research quality, use of the Delphi questionnaire, and consensus reached during meetings involving experts. Results: A total of 12 consensus recommendations for clinical application of rh-aFGF on chronic refractory wounds (CRWs) were successfully formulated, of which seven strong, four moderate, and one weak recommendations were suitable for various clinical sets. The recommendations include specifications for duration of rh-aFGF treatment, dosage, types of wounds, and its combination with other products and dressings. Conclusions: rh-aFGF has vital clinical value for healing chronic wounds. This consensus provides clinicians with a reference to guide the application not only of rh-aFGF but also of other growth factor drugs with similar mechanisms for CRWs.