Development of Biological-Window-Active Au Open-Shell Nanoparticles with High-Sensitivity Surface-Enhanced Raman Scattering Imaging Probe Properties
Kosuke Sugawa, Yuka Hori, Azusa Onozato, Hikaru Naitoh, Arisa Suzuki, Tamaki Amemiya, Hironobu Tahara, Tsuyoshi Kimura, Yasuhiro Kosuge, Keiji Ohno, Takeshi Hashimoto, Takashi Hayashita, Joe Otsuki
TL;DR
Researchers developed biocompatible gold nanoparticles that emit strong Raman signals in the near-infrared range, suitable for cellular imaging without toxic surfactants.
Contribution
A surfactant-free method to create gold open-shell nanoparticles with high SERS activity in the biological window is introduced.
Findings
AuOSNs exhibit strong NIR LSP resonance at ~793 nm, matching the 785 nm excitation wavelength.
PEGylated AuOSNs show negligible cytotoxicity and enable SERS imaging of HeLa cells.
AuOSNs modified with 4-MBA achieve SERS enhancement factors of ~10^6 in aqueous dispersion.
Abstract
The development of anisotropic gold nanostructures supporting localized surface plasmon (LSP) resonances in the near-infrared (NIR) biological window is of great interest for diagnostic and therapeutic nanotechnologies. Here, we report gold open-shell nanoparticles (AuOSNs), a symmetry-broken nanoshell architecture exhibiting strong NIR surface-enhanced Raman scattering (SERS) activity. AuOSNs were fabricated via a surfactant-free strategy combining bottom-up silica sphere assembly with a simple top-down gold deposition process, without using highly cytotoxic surfactants such as cetyltrimethylammonium bromide (CTAB). Boundary element method (BEM) simulations revealed that the asymmetric open-shell geometry induces NIR LSP resonances with pronounced electromagnetic field localization near the opening edges, depending on excitation configuration. Consistent with these predictions,…
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Taxonomy
TopicsGold and Silver Nanoparticles Synthesis and Applications · Plasmonic and Surface Plasmon Research · Laser-Ablation Synthesis of Nanoparticles