Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis
Zhongnan Hu, Hui Liu, Weihua Wu, Tayyab Ali, Adam Junka, Farukh S. Sharopov, Xuan Zou, Shisong Fang, Yanfang Sun
TL;DR
Artemisia plant extracts can fight H1N1 flu by targeting virus proteins and reducing inflammation, suggesting potential natural treatments.
Contribution
The study identifies Artemisia L. extracts as potential anti-H1N1 agents through targeting viral proteins and modulating immune pathways.
Findings
Artemisia L. extracts inhibit H1N1 virus attachment and reduce viral protein levels in vitro.
Quercetin and luteolin are key compounds with strong binding to influenza proteins.
Extracts modulate TLR4/MyD88/NF-κB pathways to suppress inflammation and viral replication.
Abstract
Background: Influenza A virus is an acute respiratory virus that spreads quickly, affects a broad range of populations, and can lead to many complications and mortality. Artemisia L. species are widely used in traditional medicine, but their antiviral potential against H1N1 remains uncertain. Methodology: Network pharmacology and molecular docking were used to computationally explore their potential function in this domain, and to investigate how their invasion mechanisms and adsorption occur. UPLC-MS/MS analysis identified the main components of the extracts. The anti-H1N1 mechanism of Artemisia L. extracts was studied in vitro. Results: Network pharmacology identified 95 key targets between Artemisia L. and IAV, with quercetin and luteolin as core active compounds. Molecular docking predicted strong binding affinities between these compounds and influenza virus proteins. UPLC-MS/MS…
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Taxonomy
TopicsInfluenza Virus Research Studies · interferon and immune responses · Thermal Regulation in Medicine