Antifungal Mechanism of 4-(4-Hydroxyphenyl)-2-butanone Against Fusarium solani
Yifan Chen, Li Zhang, Yan Chen, Wenpei Ge, Hongling Wang, Zhanying Xue, Xinran Cui, Xin Wang, Aimei Liao, Yuansen Hu, Na Liu
TL;DR
This study identifies a compound from bacteria that effectively fights the plant pathogen Fusarium solani by damaging its cell membrane and mitochondria.
Contribution
The novel contribution is the discovery of RK's antifungal mechanism against F. solani through membrane and mitochondrial disruption.
Findings
RK suppresses Fusarium solani growth effectively.
RK disrupts cell membranes and mitochondrial function in the fungus.
RK induces reactive oxygen species accumulation in fungal cells.
Abstract
Fusarium solani, a widely distributed plant pathogenic fungus, poses a significant threat to various crops due to its complex pathogenic mechanisms and being difficult to control. In this study, LC–TOF–MS analysis identified 4-(4-hydroxyphenyl)-2-butanone (RK) as a metabolite detected in Bacillus amyloliquefaciens strain M1, and a commercially available RK standard was subsequently used to evaluate its antifungal activity against F. solani. Antifungal assays demonstrated that RK effectively suppressed fungal growth. Further physiological and biochemical assays confirmed that RK disrupts the cell membrane and mitochondrial function, leading to intracellular reactive oxygen species (ROS) accumulation. This study offers new perspectives on the antifungal mechanism of RK and offers theoretical support for the development of innovative agricultural disease management strategies.
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Taxonomy
TopicsPlant chemical constituents analysis · Plant Pathogens and Fungal Diseases · Fungal Plant Pathogen Control