# Dietary Fiber in Endometriosis: Mechanisms, Evidence, and Potential Clinical Benefits—Up-to-Date Review

**Authors:** Justyna Czerniak, Michał Ciebiera, Natalia Zeber-Lubecka, Piotr Olcha

PMC · DOI: 10.3390/nu18040690 · Nutrients · 2026-02-21

## TL;DR

This review explores how dietary fiber may help reduce endometriosis risk and symptoms through effects on hormones, gut health, and inflammation.

## Contribution

A comprehensive review of current evidence and mechanisms linking dietary fiber to endometriosis.

## Key findings

- Higher fiber intake from fruits, vegetables, and whole grains is linked to lower endometriosis risk.
- Fiber-rich diets may reduce pain and improve quality of life in endometriosis patients.
- Fiber influences estrogen metabolism, gut microbiota, and inflammation, which are relevant to endometriosis.

## Abstract

Background: Endometriosis is a chronic, estrogen-dependent inflammatory disorder. It is associated with hormonal dysregulation, pelvic pain, and a reduced quality of life. Dietary factors may influence disease development and symptom severity. Objective: This article aims to summarize current evidence on the role of dietary fiber in endometriosis and to discuss the underlying biological mechanisms and clinical implications. Methods: A narrative review of the literature was conducted using peer-reviewed original research articles and review papers published in English. Studies examining dietary fiber intake, fiber-rich dietary patterns, and their associations with endometriosis risk, symptoms, estrogen metabolism, gut microbiota, and inflammation. Results: Observational studies suggest that higher dietary fiber intake, particularly from fruits, vegetables, and whole grains, may be associated with a reduced risk of endometriosis. Interventional evidence remains limited. However, available studies indicate that fiber-rich dietary patterns may contribute to pain reduction and improvements in quality of life. Conclusions: Current evidence suggests that dietary fiber may play a supportive role in the prevention and management of endometriosis through multiple interconnected biological pathways. Nevertheless, the limited number of high-quality interventional studies highlights the need for further well-designed clinical trials to clarify the therapeutic potential of fiber-rich diets as an adjunct to standard endometriosis care.

## Linked entities

- **Diseases:** endometriosis (MONDO:0005133)

## Full-text entities

- **Genes:** SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, GUSB (glucuronidase beta) [NCBI Gene 2990] {aka BG, MPS7}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CAT (catalase) [NCBI Gene 847], HDAC9 (histone deacetylase 9) [NCBI Gene 9734] {aka HD7, HD7b, HD9, HDAC, HDAC7B, HDAC9B}, FFAR2 (free fatty acid receptor 2) [NCBI Gene 2867] {aka FFA2R, GPR43}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, HDAC3 (histone deacetylase 3) [NCBI Gene 8841] {aka HD3, KDAC3, RPD3, RPD3-2}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, HDAC2 (histone deacetylase 2) [NCBI Gene 3066] {aka HD2, KDAC2, RPD3, YAF1}, FFAR3 (free fatty acid receptor 3) [NCBI Gene 2865] {aka FFA3R, GPR41}, HDAC8 (histone deacetylase 8) [NCBI Gene 55869] {aka CDA07, CDLS5, HD8, HDACL1, KDAC8, MRXS6}, HCAR2 (hydroxycarboxylic acid receptor 2) [NCBI Gene 338442] {aka GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG}, HDAC1 (histone deacetylase 1) [NCBI Gene 3065] {aka GON-10, HD1, KDAC1, RPD3, RPD3L1}
- **Diseases:** Dysbiosis (MESH:D064806), immune dysfunction (MESH:D007154), infertility (MESH:D007246), dyspareunia (MESH:D004414), Endometriosis (MESH:D004715), dysmenorrhea (MESH:D004412), pelvic pain (MESH:D017699), pain (MESH:D010146), endotoxemia (MESH:D019446), anovulation (MESH:D000858), injury to (MESH:D014947), Inflammation (MESH:D007249), gastrointestinal symptoms (MESH:D012817), dysuria (MESH:D053159), bloating (MESH:C535647), dyschezia (MESH:D003248), obese (MESH:D009765), inflammatory gynecological disorder (MESH:D005831)
- **Chemicals:** gum arabic (MESH:D006170), dextrins (MESH:D003912), Carbohydrate (MESH:D002241), hydroxypropylmethyl cellulose (MESH:D065347), starches (MESH:D013213), waxes (MESH:D014885), tannins (MESH:D013634), propionate (MESH:D011422), fructooligosaccharides (MESH:C116580), Butyrate (MESH:D002087), polysaccharides (MESH:D011134), nickel (MESH:D009532), arabinogalactans (MESH:C005653), pectins (MESH:D010368), galactomannans (MESH:C012990), estradiol (MESH:D004958), polyfructoses (MESH:C072599), Dietary Fiber (MESH:D004043), acid (MESH:D000143), oligosaccharides (MESH:D009844), maltodextrins (MESH:C008315), BA (MESH:D001647), Non-starch polysaccharides (-), phytate (MESH:D010833), polydextrose (MESH:C033375), cutin (MESH:C000521), beta-glucans (MESH:D047071), SCFA (MESH:D005232), ROS (MESH:D017382), saponins (MESH:D012503), folate (MESH:D005492), hemicellulose (MESH:C007916), inulin (MESH:D007444), cellulose (MESH:D002482), acetate (MESH:D000085), suberin (MESH:C065875), LPSs (MESH:D008070), lipid (MESH:D008055), methyl cellulose (MESH:D008747), luminal (MESH:D010634), steroid (MESH:D013256), arabinoxylans (MESH:C085118), water (MESH:D014867), estrone (MESH:D004970), Lignin (MESH:D008031)
- **Species:** Faecalibacterium prausnitzii (species) [taxon 853], Homo sapiens (human, species) [taxon 9606], Clostridium (genus) [taxon 1485], Eggerthella (genus) [taxon 84111], Akkermansia muciniphila (species) [taxon 239935], Clostridia (class) [taxon 186801], gut metagenome (species) [taxon 749906], Bacteroides sp. (species) [taxon 29523], Roseburia (genus) [taxon 841], Erysipelotrichia (class) [taxon 526524], Bacillota (clostridial firmicutes, phylum) [taxon 1239], Solanum tuberosum (potatoes, species) [taxon 4113]

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## References

99 references — full list in the complete paper: https://tomesphere.com/paper/PMC12943093/full.md

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Source: https://tomesphere.com/paper/PMC12943093