# Research Progress on the Biological Function, Disease-Driving Mechanism and Clinical Targeting Strategies of G3BP2 **Authors:** Yao Chen, Qi Deng, Li-Ling Yang, Ai-Ling Jiang, Rong Zhang, Qi-Bing Yan, Yong-Kang Wu PMC · DOI: 10.3390/molecules31040622 · Molecules · 2026-02-10 ## TL;DR This paper reviews the role of G3BP2 in various diseases and its potential as a biomarker and therapeutic target. ## Contribution The paper provides a comprehensive review of G3BP2's function and disease associations, highlighting its clinical targeting potential. ## Key findings - G3BP2 is highly expressed in multiple cancers and promotes tumor progression. - G3BP2 is linked to non-tumor diseases like viral infections and cardiovascular disorders. - The protein serves as a potential biomarker and therapeutic target for disease diagnosis and treatment. ## Abstract G3BP2 is an important RNA-binding protein that belongs to the mammalian Ras-GAP SH3 domain-binding protein (G3BP) family. Its structure enables it to bind to RNA or proteins, regulate nuclear–cytoplasmic shuttling, and participate in various functions, including cell growth, differentiation, migration, and RNA and protein metabolism. Studies have found that G3BP2 is involved in the occurrence and development of various human diseases, such as high expression across multiple tumor diseases, including gastric cancer, breast cancer, non-small-cell lung cancer, esophageal squamous cell carcinoma, colorectal cancer, and pancreatic ductal adenocarcinoma, driving the occurrence of human tumors, participating in tumor progression, and playing an essential role in promoting the proliferation, invasion, and migration of tumor cells. Additionally, G3BP2 is closely associated with various non-tumor diseases, including viral infections, as well as cardiovascular and cerebrovascular diseases. This review elucidates the role of G3BP2 in the development and progression of various diseases, identifying biomarkers and therapeutic targets for clinical diagnosis and treatment based on G3BP2. ## Linked entities - **Genes:** G3BP2 (G3BP stress granule assembly factor 2) [NCBI Gene 9908] - **Proteins:** G3BP2 (G3BP stress granule assembly factor 2) - **Diseases:** gastric cancer (MONDO:0001056), breast cancer (MONDO:0004989), non-small-cell lung cancer (MONDO:0005233), esophageal squamous cell carcinoma (MONDO:0005580), colorectal cancer (MONDO:0005575), pancreatic ductal adenocarcinoma (MONDO:0005184) ## Full-text entities - **Genes:** RABEP2 (rabaptin, RAB GTPase binding effector protein 2) [NCBI Gene 79874] {aka FRA}, USP10 (ubiquitin specific peptidase 10) [NCBI Gene 9100] {aka UBPO}, HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) [NCBI Gene 3181] {aka HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2}, EIF3A (eukaryotic translation initiation factor 3 subunit A) [NCBI Gene 8661] {aka EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta}, BAALC-AS1 (BAALC antisense RNA 1) [NCBI Gene 100499183] {aka FZD6-DT, lncFZD6}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, TRIM25 (tripartite motif containing 25) [NCBI Gene 7706] {aka EFP, RNF147, Z147, ZNF147}, PARVA (parvin alpha) [NCBI Gene 55742] {aka CH-ILKBP, MXRA2}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, IGFBP7 (insulin like growth factor binding protein 7) [NCBI Gene 3490] {aka AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1}, SRC (SRC proto-oncogene, non-receptor tyrosine kinase) [NCBI Gene 6714] {aka ASV, SRC1, THC6, c-SRC, p60-Src}, MYC (MYC proto-oncogene, bHLH transcription factor) [NCBI Gene 4609] {aka MRTL, MYCC, bHLHe39, c-Myc}, WNT3A (Wnt family member 3A) [NCBI Gene 89780], MIR23B (microRNA 23b) [NCBI Gene 407011] {aka MIRN23B, hsa-mir-23b, miRNA23B, mir-23b}, LAMP2 (lysosome associated membrane protein 2) [NCBI Gene 3920] {aka CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110}, EIF4A2 (eukaryotic translation initiation factor 4A2) [NCBI Gene 1974] {aka BM-010, DDX2B, EIF4A, EIF4F, NEDHSS, eIF-4A-II}, TSC2 (TSC complex subunit 2) [NCBI Gene 7249] {aka LAM, PPP1R160, TSC4}, LYN (LYN proto-oncogene, Src family tyrosine kinase) [NCBI Gene 4067] {aka JTK8, SAIDV, p53Lyn, p56Lyn}, Pgrmc1 (progesterone receptor membrane component 1) [NCBI Gene 53328] {aka HPR6.6, PPMR, Vema, mPR}, SPHK1 (sphingosine kinase 1) [NCBI Gene 8877] {aka SPHK}, AR (androgen receptor) [NCBI Gene 367] {aka AIS, AR8, DHTR, HPCX3, HUMARA, HYSP1}, SH2D3A (SH2 domain containing 3A) [NCBI Gene 10045] {aka NSP1}, DVL3 (dishevelled segment polarity protein 3) [NCBI Gene 1857] {aka DRS3}, CDK2 (cyclin dependent kinase 2) [NCBI Gene 1017] {aka CDKN2, p33(CDK2)}, ERO1A (endoplasmic reticulum oxidoreductase 1 alpha) [NCBI Gene 30001] {aka ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1L, ERO1LA, Ero1alpha}, NUTF2 (nuclear transport factor 2) [NCBI Gene 10204] {aka NTF-2, NTF2, PP15}, YBX1 (Y-box binding protein 1) [NCBI Gene 4904] {aka BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A}, SART3 (spliceosome associated factor 3, U4/U6 recycling protein) [NCBI Gene 9733] {aka DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb)}, CAPRIN1 (cell cycle associated protein 1) [NCBI Gene 4076] {aka CONDCAC, GPIAP1, GPIP137, GRIP137, M11S1, NEDLAAD}, TARBP2P1 (TARBP2 pseudogene 1) [NCBI Gene 6896] {aka TARBP2P, TRBP}, CHKA (choline kinase alpha) [NCBI Gene 1119] {aka CHK, CK, CKI, EK, NEDMIMS}, PRMT5 (protein arginine methyltransferase 5) [NCBI Gene 10419] {aka HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs}, MIR206 (microRNA 206) [NCBI Gene 406989] {aka MIRN206, miRNA206, mir-206}, PMP22 (peripheral myelin protein 22) [NCBI Gene 5376] {aka CIDP, CMT1A, CMT1E, DSS, GAS-3, GAS3}, NSUN2 (NOP2/Sun RNA methyltransferase 2) [NCBI Gene 54888] {aka MISU, MRT5, SAKI, TRM4}, ARL2BP (ARF like GTPase 2 binding protein) [NCBI Gene 23568] {aka BART, BART1, RP66, RP82}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, POU5F1 (POU class 5 homeobox 1) [NCBI Gene 5460] {aka OCT3, OCT4, OCT4Borf1, OTF-3, OTF3, OTF4}, Syt1 (synaptotagmin 1) [NCBI Gene 25716] {aka P65}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, STAT1 (signal transducer and activator of transcription 1) [NCBI Gene 6772] {aka CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91}, MIR217 (microRNA 217) [NCBI Gene 406999] {aka MIRN217, mir-217}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, TDRG1 (testis development related 1) [NCBI Gene 732253] {aka LINC00532, lincRNA-NR_024015}, TRIM72 (tripartite motif containing 72) [NCBI Gene 493829] {aka MG53}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, EPS8L2 (EPS8 signaling adaptor L2) [NCBI Gene 64787] {aka DFNB106, EPS8R2}, UBAP2L (ubiquitin associated protein 2 like) [NCBI Gene 9898] {aka NEDLBF, NICE-4, NICE4}, IRF3 (interferon regulatory factor 3) [NCBI Gene 3661] {aka IIAE7}, Mir363 (microRNA 363) [NCBI Gene 723852] {aka Mirn363, mir-363, mmu-mir-363}, ETV4 (ETS variant transcription factor 4) [NCBI Gene 2118] {aka E1A-F, E1AF, PEA3, PEAS3}, FOXD1 (forkhead box D1) [NCBI Gene 2297] {aka FKHL8, FREAC-4, FREAC4}, TWIST1 (twist family bHLH transcription factor 1) [NCBI Gene 7291] {aka ACS3, BPES2, BPES3, CRS, CRS1, CSO}, G3bp2 (G3BP stress granule assembly factor 2) [NCBI Gene 305240] {aka RGD1309571}, PTK2 (protein tyrosine kinase 2) [NCBI Gene 5747] {aka FADK, FADK 1, FAK, FAK1, FRNK, PPP1R71}, DKC1 (dyskerin pseudouridine synthase 1) [NCBI Gene 1736] {aka CBF5, CHINE1, DKC, DKCX, NAP57, NOLA4}, Pgrmc2 (progesterone receptor membrane component 2) [NCBI Gene 70804] {aka 4631434O19Rik, 5730409G06Rik, DG6, PMBP}, PRKCA (protein kinase C alpha) [NCBI Gene 5578] {aka AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha}, KDM4B (lysine demethylase 4B) [NCBI Gene 23030] {aka JMJD2B, MRD65, TDRD14B}, G3BP1 (G3BP stress granule assembly factor 1) [NCBI Gene 10146] {aka G3BP, HDH-VIII} - **Diseases:** pancreatic cancer (MESH:D010190), neovascularization (MESH:D016510), small-cell lung cancer (MESH:D055752), vision loss (MESH:D014786), PCa (MESH:D011471), inflammation (MESH:D007249), osteosarcoma (MESH:D012516), PDAC (MESH:D021441), injury to (MESH:D014947), neurodegeneration (MESH:D019636), febrile disease (MESH:D004194), ESCC (MESH:D000077277), head and neck cancers (MESH:D006258), cancer (MESH:D009369), retinal hemorrhages (MESH:D012166), adenocarcinoma (MESH:D000230), lung infiltration (MESH:D008171), diabetes (MESH:D003920), Lung Cancer (MESH:D008175), breathing difficulties (MESH:D004417), AD (MESH:D000544), tumorigenesis (MESH:D063646), Oral Cancer (MESH:D009062), vitreous hemorrhage (MESH:D014823), I (MESH:D006969), hemorrhage (MESH:D006470), GC (MESH:D013274), dengue fever (MESH:D003715), fibroplasia (MESH:D012178), hypoxia (MESH:D000860), cartilage degeneration (MESH:D002357), blindness (MESH:D001766), NSCLC (MESH:D002289), Head and Neck Squamous Cell Carcinoma (MESH:D000077195), chondrocyte damage (MESH:D020263), squamous cell carcinomas (MESH:D002294), psoriasis (MESH:D011565), neuroblastoma (MESH:D009447), fever (MESH:D005334), genetic disorders (MESH:D030342), OA (MESH:D010003), metabolic disorders (MESH:D008659), cardiac toxicity (MESH:D066126), Atherosclerosis (MESH:D050197), CRC (MESH:D015179), Viral Infections (MESH:D014777), carcinogenic (MESH:D011230), deaths (MESH:D003643), metastasis (MESH:D009362), hepatitis C virus (MESH:D006526), arthritis (MESH:D001168), Painful blisters (MESH:D001768), chest discomfort (MESH:D013898), Foot-and-mouth disease (MESH:D005536), vascular and (MESH:D057772), cough (MESH:D003371), DR (MESH:D003930), ischemic disease (MESH:D017202), SARS-CoV-2 infection (MESH:D000086382), retinal aneurysms (MESH:D012173) - **Chemicals:** AOM (MESH:D001397), paclitaxel (MESH:D017239), PDTC (MESH:C066229), lactate (MESH:D019344), aflatoxins (MESH:D000348), cisplatin (MESH:D002945), Benzopyridine (-), lipid (MESH:D008055), ISO (MESH:D007545), PRO2000 (MESH:C120231), glucose (MESH:D005947), alcohol (MESH:D000438) - **Species:** Human papillomavirus (species) [taxon 10566], Mus musculus (house mouse, species) [taxon 10090], Severe acute respiratory syndrome coronavirus 2 (no rank) [taxon 2697049], Foot-and-mouth disease virus (no rank) [taxon 12110], Hepatitis B virus (no rank) [taxon 10407], Homo sapiens (human, species) [taxon 9606], Helicobacter pylori (species) [taxon 210], Rattus norvegicus (brown rat, species) [taxon 10116], Betacoronavirus (genus) [taxon 694002], Dengue virus (no rank) [taxon 12637], Chikungunya virus (no rank) [taxon 37124], Flavivirus [taxon 11051] - **Cell lines:** 22Rv1 — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_1045), H1299 — Homo sapiens (Human), Lung large cell carcinoma, Cancer cell line (CVCL_0060) ## Full text _Full body text omitted 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