# Ironing Out the Deficiency: Tracking Iron in Celiac Disease Before and After the Gluten-Free Diet

**Authors:** Patricia Dillawn, Sadie Nagle, Edwin Liu, Marisa Gallant Stahl

PMC · DOI: 10.3390/nu18040590 · Nutrients · 2026-02-11

## TL;DR

This review explores how a gluten-free diet affects iron deficiency in celiac disease patients and whether it's enough to manage the deficiency.

## Contribution

The paper reviews the effectiveness of a gluten-free diet in resolving iron deficiency in celiac disease patients.

## Key findings

- Iron deficiency is common in newly diagnosed celiac disease patients.
- A gluten-free diet may not fully resolve iron deficiency in some individuals.
- Iron supplementation may be necessary alongside dietary changes.

## Abstract

Celiac disease (CeD) is a gluten-induced immune-mediated enteropathy that preferentially involves the proximal duodenum. Consequently, iron deficiency is common in CeD, impacting at least 10% of newly diagnosed individuals. In this narrative review, we aim to investigate the mechanisms, prevalence, treatment, and monitoring of iron deficiency and the impacts of a gluten-free diet (GFD) on iron deficiency in individuals with CeD. We will also review the role of and approach to iron supplementation in this population. Specifically, we will explore whether mucosal healing on a GFD is sufficient for the management of iron deficiency amongst individuals with CeD.

## Linked entities

- **Diseases:** Celiac disease (MONDO:0005130)

## Full-text entities

- **Genes:** TFRC (transferrin receptor) [NCBI Gene 7037] {aka CD71, IMD46, T9, TFR, TFR1, TR}, TF (transferrin) [NCBI Gene 7018] {aka HEL-S-71p, PRO1557, PRO2086, TFQTL1}, SLC11A2 (solute carrier family 11 member 2) [NCBI Gene 4891] {aka AHMIO1, DCT1, DMT1, NRAMP2}, HFE (homeostatic iron regulator) [NCBI Gene 3077] {aka HFE1, HH, HLA-H, MVCD7, TFQTL2}, HAMP (hepcidin antimicrobial peptide) [NCBI Gene 57817] {aka HEPC, HFE2B, LEAP1, PLTR}, RET (ret proto-oncogene) [NCBI Gene 5979] {aka CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1}, IFT122 (intraflagellar transport 122) [NCBI Gene 55764] {aka CED, CED1, CFAP80, FAP80, SPG, WDR10}
- **Diseases:** gastrointestinal infection (MESH:D005767), shortness of breath (MESH:D004417), infection (MESH:D007239), hypophosphatemia (MESH:D017674), anxiety (MESH:D001007), gastrointestinal blood loss (MESH:D016063), inflammation (MESH:D007249), gastrointestinal symptoms (MESH:D012817), headaches (MESH:D006261), pica (MESH:D010842), injury (MESH:D014947), anemia (MESH:D000740), menstrual blood loss (MESH:D004412), folate deficiency (MESH:C562799), visual disturbances (MESH:D014786), H. Pylori (MESH:D016481), malabsorption (MESH:D008286), iron deficiency anemia (MESH:D018798), chronic gastritis (MESH:D005756), enteropathy (MESH:C538273), neurologic symptoms (MESH:D009461), anemia of chronic disease (MESH:D002908), Iron deficiency (MESH:D000090463), CeD (MESH:D002446), hemochromatosis (MESH:D006432), gastrointestinal bleeding (MESH:D006471), mucosal injury (MESH:D052016), depression (MESH:D003866), villous atrophy (MESH:C564019), cardiac symptoms (MESH:D006331), chest pain (MESH:D002637), fatigue (MESH:D005221)
- **Chemicals:** heme (MESH:D006418), ferrous sulfate (MESH:C020748), vitamin D (MESH:D014807), Fe2+ (-), ferric carboxymaltose (MESH:C522335), vitamin C (MESH:D001205), folate (MESH:D005492), calcium (MESH:D002118), B12 (MESH:C034730), Iron (MESH:D007501)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** IVS4+44C>A

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12943008/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12943008/full.md

## References

66 references — full list in the complete paper: https://tomesphere.com/paper/PMC12943008/full.md

---
Source: https://tomesphere.com/paper/PMC12943008