# Knowledge and Perceptions of Parents and Adolescents Regarding HPV and Its Vaccine

**Authors:** Eleni Tsimpou, Anastasia Bothou, Christina I Nanou, Giannoula A Kyrkou, Pinelopi Varela, Athina Diamanti, Victoria Vivilaki, Anna Deltsidou

PMC · DOI: 10.7759/cureus.102411 · Cureus · 2026-01-27

## TL;DR

This study explores how parents and teens in Greece understand HPV and the vaccine, finding that knowledge and communication influence vaccination intentions.

## Contribution

The study identifies key factors like parental communication and gender that influence HPV vaccine intentions among adolescents.

## Key findings

- 89.3% of parents were aware of HPV, and 82.8% supported vaccination.
- Female adolescents and those who discussed STDs with parents were more likely to intend to get vaccinated.
- Higher parental education and female gender correlated with better HPV knowledge.

## Abstract

Background

Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several malignancies. Understanding parental and adolescent knowledge and perceptions regarding HPV and its vaccine is essential for improving vaccination uptake.

Methods

This cross-sectional study was conducted between April and May 2023 in a health center in Northern Greece. Questionnaires were completed by 151 parents and 152 adolescents aged 11-18 years. Data were analyzed using descriptive statistics and multivariable regression analyses.

Results

Among parents, 89.3% were aware of HPV, and 82.8% were generally in favor of vaccination. Higher HPV knowledge scores were observed among women and participants with higher educational levels (p < 0.001 and p = 0.001, respectively). Among adolescents, 63.6% expressed intention to receive the HPV vaccine. Female gender (odds ratio (OR) = 2.16, 95% confidence interval (CI): 1.05-4.46) and discussion with parents about sexually transmitted diseases (STDs) were independently associated with vaccination intention. Older age was positively associated with higher HPV knowledge scores among adolescents (p < 0.001).

Conclusions

Both parents and adolescents demonstrated substantial awareness of HPV infection and its prevention. Parental communication and adolescents’ gender were important factors associated with vaccination intention, highlighting the need for targeted educational interventions to enhance HPV vaccine uptake.

## Full-text entities

- **Diseases:** diseases (MESH:D004194), warts (MESH:D014860), cervical cancer (MESH:D002583), STD (MESH:D012749), cancer (MESH:D009369), sexually (MESH:D050035), uterine cancer (MESH:D014594), anxiety (MESH:D001007), HPV infection (MESH:D030361), cervical lesions (MESH:D002575), carcinogenic infection (MESH:D007239)
- **Chemicals:** Q18 (-)
- **Species:** Human papillomavirus (species) [taxon 10566], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12942967/full.md

## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12942967/full.md

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Source: https://tomesphere.com/paper/PMC12942967