# Drimane Sesquiterpenes Isolated from the Fruiting Body of the Clavarioid Fungus Ramaria botrytoides

## TL;DR

Researchers discovered four new drimane-type compounds in a fungus, expanding the known chemical diversity of this species.

## Contribution

The discovery of four new drimane sesquiterpenoids with rare structural features expands fungal secondary metabolite diversity.

## Key findings

- Four new drimane-type sesquiterpenoids (ramaribotrytols A–D) were isolated from Ramaria botrytoides.
- The compounds feature rare oxygenation at C-2, a novel structural characteristic in drimane sesquiterpenoids.
- The findings enrich the structural diversity of drimane-type metabolites from higher fungi.

## Abstract

Four previously undescribed drimane-type sesquiterpenoids, ramaribotrytols A–D (1–4), were isolated from the fruiting bodies of the clavarioid fungus Ramaria botrytoides. Their structures and absolute configurations were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. Compounds 1–4 are characterized by oxygenation at C-2, a structural feature that is rare within the drimane sesquiterpene family. These findings expand the chemical diversity of secondary metabolites from the medicinal and edible fungus Ramaria and enrich the structural repertoire of drimane-type sesquiterpenoids derived from higher fungi.