# Consumer Perceptions Influence Supplement Choice: A Narrative Review of Clinically Studied Weight-Management Supplements in Obesity

**Authors:** Hyeonseok Lee, Jung Hyun Kwak

PMC · DOI: 10.3390/nu18040702 · Nutrients · 2026-02-22

## TL;DR

This review examines weight-loss supplements like L-carnitine and green tea extract, finding mixed evidence on their effectiveness and highlighting how consumer perceptions influence supplement choices.

## Contribution

The study provides a narrative review of four weight-management supplements, emphasizing the need for evidence-based and context-aware supplement selection.

## Key findings

- Some studies show improvements in weight and metabolic indicators with supplements like L-carnitine and green tea extract.
- Scientific evidence for the efficacy of these supplements remains inconsistent.
- Consumer choices are often influenced by subjective beliefs rather than objective evidence.

## Abstract

Obesity is a major public health problem with a continuously increasing global prevalence and is associated with various chronic diseases and substantial social and economic burdens. As dietary modification and physical activity alone often have limited effectiveness in achieving sustained weight loss, dietary supplements intended for weight reduction are widely used. However, evidence on the efficacy and safety of these supplements is inconsistent, and consumer use intentions tend to be driven by subjective beliefs and insurance-like perceptions. Accordingly, this study reviewed recent evidence on L-carnitine, green tea extract, glucomannan, and Garcinia cambogia, supplements for which weight loss effects have been proposed, to assess their efficacy and safety and to highlight the importance of supplement selection aligned with consumer use contexts. PubMed, MEDLINE, and Google Scholar databases were searched for studies published between 1 January 2020 and 10 October 2025. Although some studies have reported improvements in weight and metabolic indicators, consistent scientific evidence has not yet been established. This review emphasized the need for purpose-driven supplement selection that integrates efficacy, safety, usage context, and evidence level, and the importance of consumers’ critical information appraisal capacity, supported by structured information provision and education.

## Linked entities

- **Chemicals:** L-carnitine (PubChem CID 288), glucomannan (PubChem CID 24892726)
- **Diseases:** obesity (MONDO:0011122)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, LPA (lipoprotein(a)) [NCBI Gene 4018] {aka AK38, APOA, LP}, APOA1 (apolipoprotein A1) [NCBI Gene 335] {aka AMYLD3, HPALP2, apo(a)}, CPT1A (carnitine palmitoyltransferase 1A) [NCBI Gene 1374] {aka CPT I, CPT1, CPT1-L, CPTI-L, L-CPT1}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, LEP (leptin) [NCBI Gene 3952] {aka LEPD, OB, OBS}, ACLY (ATP citrate lyase) [NCBI Gene 47] {aka ACL, ATPCL, CLATP}, LIPE (lipase E, hormone sensitive type) [NCBI Gene 3991] {aka AOMS4, FPLD6, HSL, LHS, REH}, APOB (apolipoprotein B) [NCBI Gene 338] {aka FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48}, AIP (AHR interacting HSP90 co-chaperone) [NCBI Gene 9049] {aka ARA9, FKBP16, FKBP37, PITA1, SMTPHN, XAP-2}
- **Diseases:** acute pancreatitis (MESH:D010195), dizziness (MESH:D004244), Insulin Resistance (MESH:D007333), knee osteoarthritis (MESH:D020370), cytotoxicity (MESH:D064420), Weight Loss (MESH:D015431), acute hepatitis (MESH:D017114), esophageal or gastrointestinal disease (MESH:D005767), cancer (MESH:D009369), insomnia (MESH:D007319), cardiovascular disease (MESH:D002318), NAFLD (MESH:D065626), hypertension (MESH:D006973), PCOS (MESH:D011085), dyslipidemia (MESH:D050171), hyperinsulinemia (MESH:D006946), serotonin (MESH:D020230), hyperlipidemia (MESH:D006949), metabolic syndrome (MESH:D024821), hyperglycemia (MESH:D006943), injury to (MESH:D014947), headache (MESH:D006261), inflammation (MESH:D007249), gastrointestinal symptoms (MESH:D012817), visceral adiposity (MESH:D007418), iron-deficiency anemia (MESH:D018798), diet-related diseases (MESH:D000077733), metabolic (MESH:D008659), diarrhea (MESH:D003967), overweight (MESH:D050177), liver injury (MESH:D017093), palpitations (MESH:D006331), constipation (MESH:D003248), hepatocellular injury (MESH:D056486), nausea (MESH:D009325), depression (MESH:D003866), musculoskeletal pain (MESH:D059352), Obesity (MESH:D009765), tachycardia (MESH:D013610), renal or hepatic diseases (MESH:D007674), abdominal bloating (MESH:D000007), type 2 diabetes (MESH:D003924), weight gain (MESH:D015430)
- **Chemicals:** Glucomannan (MESH:C022901), carbon (MESH:D002244), fatty acid (MESH:D005227), carbohydrate (MESH:D002241), mangostin (MESH:C021053), TG (MESH:D014280), agar (MESH:D000362), phenols (MESH:D010636), propionate (MESH:D011422), amino acid (MESH:D000596), butyrate (MESH:D002087), acyl-CoA (MESH:D000214), phloroglucinols (MESH:D010696), thiol (MESH:D013438), L-Carnitine (MESH:D002331), benzophenones (MESH:D001577), garcinol (MESH:C054597), trimethylamine N-oxide (MESH:C005855), bile acid (MESH:D001647), GTE (-), methionine (MESH:D008715), FAT (MESH:D005223), TGs (MESH:C026285), EGCG (MESH:C045651), blood glucose (MESH:D001786), SCFA (MESH:D005232), reactive oxygen species (MESH:D017382), D-glucose (MESH:D005947), creatinine (MESH:D003404), serotonin (MESH:D012701), flavonoids (MESH:D005419), cholesterol (MESH:D002784), thiobarbituric acid reactive substances (MESH:D017392), alkaloids (MESH:D000470), GC (MESH:C057580), acetyl-L-carnitine (MESH:D000108), inulin (MESH:D007444), PGX (MESH:D011464), biphenyls (MESH:C010574), lysine (MESH:D008239), (-)-hydroxycitric acid (MESH:C007999), catechin (MESH:D002392), malonyl-CoA (MESH:D008316), acetyl-CoA (MESH:D000105), lipid (MESH:D008055), glycogen (MESH:D006003), GSH (MESH:D005978), xanthones (MESH:D044004), water (MESH:D014867), polyphenol (MESH:D059808)
- **Species:** Homo sapiens (human, species) [taxon 9606], Amorphophallus konjac (devil's-tongue, species) [taxon 78372], Mus musculus (house mouse, species) [taxon 10090], Akkermansia muciniphila (species) [taxon 239935], Garcinia (genus) [taxon 58227], Camellia sinensis (black tea, species) [taxon 4442]

## Full text

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## References

99 references — full list in the complete paper: https://tomesphere.com/paper/PMC12942658/full.md

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Source: https://tomesphere.com/paper/PMC12942658