Corallomycetellains A–J, Cytotoxic Epipolythiodioxopiperazine Alkaloids Isolated from the Fungi Corallomycetella repens HDN23-0007
Chenqi Zhang, Luning Zhou, Shuo Zhao, Wenxue Wang, Xiaomin Zhang, Qian Che, Tianjiao Zhu, Mei Han, Dehai Li
TL;DR
Researchers discovered ten new toxic compounds from a fungus that show strong anticancer properties in lab tests.
Contribution
The discovery of ten new ETP alkaloids with unique structural features and potent cytotoxic activity.
Findings
Compounds 7–10 showed strong anticancer activity with IC50 values between 1.1 and 9.3 μM.
Compounds 1–2 are the first aranotin-type ETPs with an aromatic indole group.
Compound 4 has a unique C2′-oxomethyl group in addition to a C2-methyl disulfide substituent.
Abstract
Ten new epipolythiodioxopiperazine (ETP) alkaloids, named corallomycetellains A–J (1–10), along with one known analogue, haematocin (11), were isolated from the fungi Corallomycetella repens HDN23-0007. Their structures, including absolute configurations, were established by comprehensive spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1–2 represent the first two examples of aranotin-type ETPs possessing an aromatic indole moiety. Compounds 2–4 all featured a unique C2-methyl disulfide substituent, whereas compound 4 additionally possessed a C2′-oxomethyl group. In in vitro cytotoxicity assays, compounds 7–10, which contained α–α′ polysulfide bridges, exhibited strong anticancer activity, with IC50 values ranging from 1.1 to 9.3 μM.
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Taxonomy
TopicsMicrobial Natural Products and Biosynthesis · Marine Sponges and Natural Products · Seaweed-derived Bioactive Compounds