Targeting the Cardiovascular-Alzheimer’s Disease Axis: The Promise of Marine Bioactive Peptides
Chathuri Kaushalya Marasinghe, Kumju Youn, Chi-Tang Ho, Mira Jun
TL;DR
This review explores how marine bioactive peptides can help prevent both cardiovascular and Alzheimer’s diseases by targeting shared mechanisms.
Contribution
The paper introduces marine bioactive peptides as a novel, sustainable approach for integrated prevention of CVD and AD.
Findings
Marine bioactive peptides show antioxidant, anti-inflammatory, and neuroprotective properties relevant to the CVD-AD axis.
Enzymatic hydrolysis and separation techniques are key for producing and characterizing these peptides.
Challenges include scalable production and regulatory approval, though progress is being made.
Abstract
Cardiovascular diseases (CVDs) and Alzheimer’s disease (AD) are among the most prevalent chronic conditions, contributing significantly to global morbidity and healthcare burdens. These diseases are increasingly recognized as interconnected through shared mechanisms such as vascular dysfunction, oxidative stress, hypertension, and systemic inflammation, collectively referred to as the CVD-AD axis. Although therapeutic strategies exist for each condition, integrated approaches targeting these common pathways remain limited. This review highlights marine-derived bioactive peptides (BAPs) as multifunctional, sustainable agents for the simultaneous prevention of CVD and AD. It summarizes recent advances in their production, purification, and characterization, with emphasis on enzymatic hydrolysis and separation techniques. Marine BAPs exhibit diverse bioactivities, antioxidant,…
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Taxonomy
TopicsProtein Hydrolysis and Bioactive Peptides · Seaweed-derived Bioactive Compounds · GDF15 and Related Biomarkers