The Impact of Near-Infrared Spectroscopy in Early Detection of Cerebral Deterioration After Aneurysmal Subarachnoid Haemorrhage

TL;DR

This study explores how near-infrared spectroscopy can detect early signs of brain issues in patients after a specific type of brain hemorrhage.

Contribution

The study introduces new insights into the use of NIRS as a non-invasive tool for monitoring cerebral deterioration in aSAH patients.

Findings

NIRS showed high sensitivity but low specificity for detecting cerebral vasospasm.

NIRS had high diagnostic accuracy for predicting delayed cerebral ischemia.

Lower rSO2 values correlated with worse patient outcomes and longer ICU stays.

Abstract

Background/Objectives: Delayed cerebral ischemia (DCI) represents a major cause of morbidity and mortality after aneurysmal subarachnoid haemorrhage (aSAH). Early identification of developing cerebral ischemia is essential for timely prevention of DCI. Near-infrared spectroscopy (NIRS) provides continuous, non-invasive bedside monitoring of regional cerebral oxygen saturation (rSO2); however, its clinical value in patients with aSAH has not yet been fully established. The primary objective of this study was to investigate whether NIRS-detected rSO2 desaturation can serve as an early indicator of cerebral vasospasm (CV) and predict the occurrence of DCI. Secondary objectives were to examine the associations between rSO2 changes and other cerebral deterioration events, length of intensive care unit stay, functional outcome, and in-hospital mortality. Methods: This prospective, single-centre study included 30 patients with aSAH admitted to the intensive care unit (ICU) of Riga East University Hospital between January 2019 and January 2023. Bilateral frontal near-infrared spectroscopy (NIRS) monitoring (Covidien INVOS™ 5100C-PB) was initiated within 72 h after ictus and continued for up to 7 days. Cerebral desaturation was defined as a >20% reduction from baseline (BL) or an absolute regional cerebral oxygen saturation (rSO2) value < 50% lasting ≥30 min. CV and DCI were diagnosed according to established clinical and radiological criteria. Receiver operating characteristic (ROC) analysis was performed to evaluate the sensitivity and specificity of rSO2 thresholds for the detection of CV, DCI, and other cerebral deterioration events. Results: CV occurred in 10 patients (33%); however, only four cases were detected during the NIRS monitoring period. NIRS demonstrated very high sensitivity (97.5%) but extremely low specificity (6%) for the early detection of CV. In contrast, diagnostic accuracy for DCI was high. An absolute rSO2 cut-off value of 52% yielded a sensitivity of 97.5% and a specificity of 95%, whereas a decrease of ≥26% from baseline (BL) demonstrated a sensitivity of 98% and a specificity of 93%. Significant rSO2 reductions were also observed during aneurysm re-rupture, hydrocephalus, cerebral edema, and postoperative ischemia; however, the sensitivity of NIRS for detecting these events was negligible. Patients with ≥20% desaturation tended to have longer ICU stays, and lower mean rSO2 values as well as greater desaturation were associated with poorer functional outcomes as assessed by the modified Rankin Scale. Patients who died exhibited more pronounced rSO2 decreases and less recovery compared with survivors. Conclusions: In this cohort, NIRS demonstrated limited specificity for the early detection of CV but showed strong associations with DCI and neurological outcome. NIRS may be useful as a non-invasive adjunct to multimodal neuromonitoring rather than as a stand-alone diagnostic tool for cerebral vasospasm. Larger, prospective studies incorporating standardized imaging protocols and optimized rSO2 thresholds are required to more clearly define the role of NIRS in the management of aSAH.

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