# Comment on Othman et al. Ventricular Topology in Congenital Heart Defects Associated with Heterotaxy: Can We Find Patterns Reflecting the Syndrome-Specific Tendency for Visceral Symmetry? J. Cardiovasc. Dev. Dis. 2025, 12, 430

**Authors:** Flaminia Pugnaloni, Giulio Calcagni, Bruno Marino

PMC · DOI: 10.3390/jcdd13020067 · 2026-01-27

## Full-text entities

- **Genes:** ZIC3 (Zic family zinc finger 3) [NCBI Gene 7547] {aka HTX, HTX1, VACTERLX, ZNF203}
- **Diseases:** situs inversus (MESH:D012857), corrected (MESH:D000080041), injury to (MESH:D014947), atrial situs solitus (MESH:D002278), DORV (MESH:D004310), pulmonary atresia (MESH:D018633), LI (MESH:D016864), cardiac defects (MESH:D006331), RI (MESH:C564256), heterotaxy (MESH:D059446), TGA (MESH:D014188), CHDs (MESH:D006330)
- **Species:** Homo sapiens (human, species) [taxon 9606]

---
Source: https://tomesphere.com/paper/PMC12942002