# Clinical Therapeutic and Management Strategies for Epilepsy: Psychological Aspects in Children with Epilepsy and Their Parents

**Authors:** Hideaki Kanemura

PMC · DOI: 10.3390/jcm15041670 · 2026-02-23

## TL;DR

Epilepsy in children affects their quality of life through psychological and social issues, and managing these aspects can improve outcomes.

## Contribution

The paper highlights the psychological and social impact of epilepsy in children and emphasizes the role of parental anxiety and educational interventions in improving quality of life.

## Key findings

- Seizure frequency is linked to stigma, fatigue, and headaches in children with epilepsy.
- Parental anxiety can lead to dysfunctional adaptation in children with refractory epilepsy.
- Educational interventions for parents can reduce negative emotional impacts and improve child outcomes.

## Abstract

Epileptic activities can affect various aspects including neuropsychological and social functions, which lead to reductions in quality of life (QOL) for epileptic children. Social function in epileptic children can be negatively impacted due to emotional instability, including stigma associated with having epilepsy. The parents of children with refractory epilepsy could experience severe anxiety regarding clinical seizures in their children, and this severe parental anxiety state could lead to adaptable dysfunction in their children. Moreover, associations between epilepsy and fatigue or headache are well known to clinicians but insufficiently understood. A deeper understanding of these issues in epilepsy could be important for managing the clinical course and treatment regimen. Seizure activities could be associated with impaired neuropsychological/social functions as represented by stigma, fatigue, and headache. Seizure severities are thus important QOL-related factors in terms of neuropsychological and social issues in epileptic children. A relationship between current seizure activity and perception of stigma could be evident in epileptic children. Seizure activity represented as frequent seizures could also be related to fatigue and seizure-associated headache, which can lead to reduced QOL in children with epilepsy. In addition, seizure-related factors in epileptic children including frequent seizures could lead to a greater perception of stigma among their parents. Meanwhile, educational interventions about epilepsy for parents could reduce negative emotional influences when caring for children presenting with seizure attacks. Therapeutic management thus appears desirable to achieve better seizure control and establish educational support for parents, aiming to improve QOL in children with epilepsy.

## Linked entities

- **Diseases:** epilepsy (MONDO:0005027)

## Full-text entities

- **Genes:** PSS (Potocki-Shaffer syndrome) [NCBI Gene 780904]
- **Diseases:** depression (MESH:D003866), social (OMIM:300082), dysfunction (MESH:D006331), IEDs (MESH:D019522), migraines (MESH:D008881), panic (MESH:D016584), neurodevelopmental disorders (MESH:D002658), parenting dysfunction (MESH:D063129), cognitive declines (MESH:D003072), Epilepsy (MESH:D004827), brain damage (MESH:D001925), impairment of consciousness (MESH:D003244), death (MESH:D003643), FLE (MESH:D017034), attention-deficit/hyperactivity disorder (MESH:D001289), epileptic syndromes (MESH:D000073376), impaired awareness (MESH:D058926), social dysfunctions (MESH:D000067404), neurological diseases (MESH:D020271), Fatigue (MESH:D005221), refractory epilepsy (MESH:D000069279), neurological disorder (MESH:D009461), Seizures (MESH:D012640), injury to (MESH:D014947), neurological condition (MESH:D019636), shock (MESH:D012769), paroxysmal disorders (MESH:D009290), Headache (MESH:D006261), paroxysmal (MESH:D002819), impaired growth of the prefrontal lobe (MESH:D006130), autism spectrum disorder (MESH:D000067877), CSS (MESH:C538175), FS (MESH:D052159), weakness (MESH:D018908), dying (MESH:D064806), impairments of (MESH:D060825), behavioral disturbances (MESH:D001523), motion arrest (MESH:D009041), Anxieties (MESH:D001007), deviation (MESH:D010262), FSs (MESH:D003294)
- **Chemicals:** Carbamazepine (MESH:D002220), PER (MESH:C551441), LEV (MESH:D000077287), lacosamide (MESH:D000078334), Zonisamide (MESH:D000078305)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12941972/full.md

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Source: https://tomesphere.com/paper/PMC12941972