# Emerging Biomaterials for Maxillary Sinus Augmentation: From In Vitro Insights to In Vivo Clinical Translation

## TL;DR

This paper reviews new biomaterials for maxillary sinus augmentation that aim to improve bone regeneration compared to traditional materials.

## Contribution

The paper provides a critical review of recent biomaterial innovations and their potential for clinical translation in sinus augmentation.

## Key findings

- Next-generation graft materials aim to enhance vascularization and osteogenesis.
- Ion-releasing ceramics and growth factor-enhanced allografts show promise in overcoming DBBM limitations.
- Integrated preclinical and clinical research is essential for successful biomaterial translation.

## Abstract

Maxillary sinus augmentation is a key procedure for rehabilitating the atrophic posterior maxilla and enabling predictable implant-supported restorations. Although autogenous bone remains the biological gold standard due to its osteogenic potential, its clinical use has declined because of donor-site morbidity, limited availability, and increased surgical burden. Deproteinized bovine bone mineral (DBBM) is currently the most widely used substitute, providing excellent biocompatibility and long-term volumetric stability. However, its inert nature, limited bioactivity, and slow resorption have driven the development of next-generation graft materials. Recent biomaterial innovations aim to enhance vascularization, accelerate osteogenesis, modulate immune responses, and achieve controlled resorption while maintaining favorable handling properties. These include ion-releasing bioactive ceramics, growth factor-enhanced allografts, polysaccharide–hydroxyapatite composites, smart hydrogels, and synthetic scaffolds with tunable degradation profiles. Given the complexity of bone regeneration, effective clinical translation requires an integrated framework combining in vitro assays, animal models, and human clinical studies. This review synthesizes evidence published since 2018 on emerging biomaterials for sinus floor elevation, critically evaluating their potential to overcome the limitations of DBBM and highlighting the importance of a coordinated preclinical-to-clinical research continuum.