# United Airway Disease: An Evolving Concept? A Scoping Review of the Modern Literature on Integrated Treatment Approaches

## TL;DR

This review explores treatment approaches that address both upper and lower airway diseases together, finding that integrated methods like biological therapies and nasal irrigation are effective and safe.

## Contribution

The paper provides a scoping review of modern literature on integrated treatment approaches for united airway disease.

## Key findings

- Biological treatments like dupilumab and non-biological methods are effective for upper and lower airway diseases.
- Integrated approaches show a good safety profile and improve patient outcomes.
- The review highlights the importance of considering combined treatment strategies for airway diseases.

## Abstract

Background: This scoping review screens modern literature in search of effective treatment approaches that target both upper and lower airway diseases. Methods: After the establishment of a research protocol, 227 potential articles were obtained through a logged search method. These were screened and narrowed down to 26 included articles. Data were extracted using a standardized data extraction form and were analyzed thematically and analytically. Results: The main integrated treatment approaches are biological (dupilumab was the most mentioned molecule) and non-biological (allergen immunotherapy, nasal saline irrigation, and endoscopic polypectomy). Data suggest that these approaches are effective in improving upper and lower airway outcomes and showcase a good safety profile. Conclusions: Patients with upper and lower airway diseases should benefit from integrated treatment approaches when possible.