# Severe HAPE in a Remote High-Altitude Research Station in Antarctica

**Authors:** Fanny Larcher, Paul Laforet, Stephane Fraize, Mario Lecca, Riccardo Scipinotti, Gianluca Bianchi Fasani, Salvatore Vagnoni, Sascha Freigang

PMC · DOI: 10.3390/life16020313 · 2026-02-11

## TL;DR

A case of severe high altitude pulmonary edema is reported and managed at a remote Antarctic research station, highlighting the importance of prompt medical action in extreme environments.

## Contribution

This paper presents a real-world case of HAPE management in a remote high-altitude setting, emphasizing the effectiveness of immediate diagnostics and evacuation strategies.

## Key findings

- A technician at Concordia Station developed severe HAPE three days after arrival.
- Use of high-flow oxygen and a mobile hyperbaric chamber, followed by evacuation, led to successful recovery.
- Prompt medical intervention and evacuation within 24 hours were critical for the patient's recovery.

## Abstract

Isolated, confined, and extreme environments hold the opportunity to collect unique biomedical data. These often-remote places present specific medical challenges for deployed expeditioners. Here we report a case of acute severe high altitude pulmonary oedema (HAPE) and its management at a remote research station in Antarctica. At the beginning of the 2023 summer campaign at Concordia Station (3200 m AMSL), a technician presented with shortness of breath and compromised circulation three days after arrival on site. Immediate diagnostics and medical treatments with high-flow oxygen and the use of a mobile hyperbaric chamber after initial resuscitation were administered. Within a time window of 24 h, evacuation to sea level was organised via aircraft (flight duration 4 h, non-pressurised cabin) inside the mobile hyperbaric chamber. The patient was discharged from medical treatment 48 h later in Christchurch (NZ). We conclude that despite rigorous pre-deployment screening, even experienced expeditioners can develop critical medical conditions that require prompt reaction and rescue. Structured assessment tools can aid in their recognition and management.

## Linked entities

- **Diseases:** high altitude pulmonary oedema (MONDO:0021811)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** frontal headache (MESH:D006261), injury to (MESH:D014947), disease (MESH:D004194), respiratory infections (MESH:D012141), cyanosis (MESH:D003490), HACE (MESH:C535833), AMS (MESH:D000532), shortness of breath (MESH:D004417), pulmonary oedema (MESH:D011654), tachycardia (MESH:D013610), opacities (MESH:D003318), pneumonia (MESH:D011014), Hypoxia (MESH:D000860), oedema (MESH:C536897), fire (MESH:D000092422), coughing (MESH:D003371), cardiac failure (MESH:D006333), pulmonary artery atresia (MESH:D018633), open foramen ovale (MESH:D054092)
- **Chemicals:** paracetamol (MESH:D000082), O2 (MESH:D010100), Nifedipine (MESH:D009543), pCO2 (-), Na (MESH:D012964), K (MESH:D011188), HCO3 (MESH:D001639), creatinine (MESH:D003404)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** A 490 L

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12941443/full.md

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Source: https://tomesphere.com/paper/PMC12941443