# Estimating and Ranking of Common Cancers in South Africa’s Eastern Cape and Mpumalanga Provinces: A Patient Survey in Three Referral Hospitals

**Authors:** Ntiyiso Vinny Khosa, Eric Maimela, Bongiwe Esther Mkabela, Khanyisile Masuku, Verona Witbooi, Nolusindiso Ncitakalo, Thokoe Vincent Makola, Siyonela Mlonyeni, Nomfuneko Sithole

PMC · DOI: 10.3390/ijerph23020211 · International Journal of Environmental Research and Public Health · 2026-02-09

## TL;DR

This study surveyed patients in three South African hospitals to identify the most common cancers in the Eastern Cape and Mpumalanga provinces.

## Contribution

The study provides province-specific cancer prevalence data from patient surveys in under-researched regions of South Africa.

## Key findings

- Breast cancer was the most prevalent with 37.65% of cases.
- Cervical cancer followed with 19.06% of cases.
- Prostate cancer accounted for 12% of cases.

## Abstract

Background: Cancer is a rising public health concern in South Africa, with varying incidence and prevalence trends between provinces. Objectives: This study aimed to investigate the approach to estimating and ranking common cancers in South Africa’s Eastern Cape and Mpumalanga provinces through a patient survey in three referral hospitals. Methods: A quantitative cross-sectional design was employed from 1 April 2022 to 31 July 2022. A total of 425 patients were recruited to participate in this study. Patients were purposively sampled. Pretests were conducted to determine the reliability and validity of the instruments. Data were coded in Microsoft Excel and Stata; version 18 was used for data analysis. Ethical principles were observed and ensured throughout the study. Results: The results show the highest prevalence as breast cancer with 37.65% representing 160 cases, followed by cervical cancer with 19.06% (81 cases), and prostate cancer with 12.00% (51 cases). Conclusions: This study provided valuable insights into the prevalence and distribution of common cancers in the Eastern Cape and Mpumalanga provinces of South Africa based on data collected from patients across three referral hospitals.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989), cervical cancer (MONDO:0002974), prostate cancer (MONDO:0005159)

## Full-text entities

- **Genes:** KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}
- **Diseases:** HICs (MESH:D008228), breast, ovarian, and pancreatic cancers (MESH:D010051), Lymphomas (MESH:D008223), obesity (MESH:D009765), Breast cancer (MESH:D001943), Non-melanoma skin cancers (MESH:D012878), squamous cell carcinoma (MESH:D002294), EC (MESH:C537835), immune dysregulation (OMIM:614878), HIV (MESH:D015658), liver cancer (MESH:D006528), Oncology (MESH:D000072716), basal cell carcinoma (MESH:D002280), thyroid cancer (MESH:D013964), Deaths (MESH:D003643), breast, cervical, colorectal, and uterine (MESH:D061325), Cervical cancer (MESH:D002583), CRC (MESH:D015179), disease (MESH:D004194), injury to (MESH:D014947), RFH (MESH:D003428), Prostate cancer (MESH:D011471), APC (MESH:D011125), substance abuse (MESH:D019966), infection (MESH:D007239), lung cancer (MESH:D008175), diabetes (MESH:D003920), male-specific cancers (MESH:D018567), immune (MESH:D007154), Cancers (MESH:D009369)
- **Chemicals:** alcohol (MESH:D000438)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Human immunodeficiency virus 1 (no rank) [taxon 11676], Human papillomavirus (species) [taxon 10566], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12941374/full.md

## References

55 references — full list in the complete paper: https://tomesphere.com/paper/PMC12941374/full.md

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Source: https://tomesphere.com/paper/PMC12941374