# Special Issue “Anticancer Drug Discovery Based on Natural Products”

**Authors:** Su-Yun Lyu

PMC · DOI: 10.3390/ijms27041675 · International Journal of Molecular Sciences · 2026-02-09

## Full-text entities

- **Genes:** DCT (dopachrome tautomerase) [NCBI Gene 1638] {aka OCA8, TRP-2, TYRP2}, TYR (tyrosinase) [NCBI Gene 7299] {aka ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3}, TYRP1 (tyrosinase related protein 1) [NCBI Gene 7306] {aka CAS2, CATB, GP75, OCA3, TRP, TRP1}, PARP1 (poly(ADP-ribose) polymerase 1) [NCBI Gene 142] {aka ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1}, MITF (melanocyte inducing transcription factor) [NCBI Gene 4286] {aka CMM8, COMMAD, MI, MITF-A, WS2, WS2A}, TCEAL1 (transcription elongation factor A like 1) [NCBI Gene 9338] {aka HIJRS, NEDGFAX, SIIR, WEX9, p21, pp21}, CYP2C9 (cytochrome P450 family 2 subfamily C member 9) [NCBI Gene 1559] {aka CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9}, ITGAM (integrin subunit alpha M) [NCBI Gene 3684] {aka CD11B, CR3A, HNA-4, MAC-1, MAC1A, MO1A}, MAPK14 (mitogen-activated protein kinase 14) [NCBI Gene 1432] {aka CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2}, MAPK1 (mitogen-activated protein kinase 1) [NCBI Gene 5594] {aka ERK, ERK-2, ERK2, ERT1, MAPK2, NS13}, MAPK8 (mitogen-activated protein kinase 8) [NCBI Gene 5599] {aka JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8}
- **Diseases:** phototoxicity (MESH:D017484), AML (MESH:D015470), hematological malignancies (MESH:D019337), injury to (MESH:D014947), Prostate Cancer (MESH:D011471), Melanoma (MESH:D008545), Cancer (MESH:D009369), Head and Neck Cancer (MESH:D006258), Breast Cancer (MESH:D001943), androgen (MESH:D014770), deaths (MESH:D003643), tumorigenic (MESH:D002471), Colon Cancer (MESH:D015179), cytotoxic (MESH:D064420)
- **Chemicals:** genistein (MESH:D019833), Picroside III (MESH:C000604655), resveratrol (MESH:D000077185), 2'-hydroxyflavone (MESH:C056011), quercetin (MESH:D011794), vincristine (MESH:D014750), paclitaxel (MESH:D017239), chlorophyll (MESH:D002734), Enzalutamide (MESH:C540278), Lipid (MESH:D008055), melanin (MESH:D008543), naringenin (MESH:C005273), Olaparib (MESH:C531550), camptothecin (MESH:D002166), ellagic acid (MESH:D004610), Talazoparib (MESH:C586365), Docetaxel (MESH:D000077143), ROS (-)
- **Species:** Ganoderma leucocontextum (species) [taxon 1566825], Glycine max (soybean, species) [taxon 3847], Hippophae rhamnoides (sallowthorn, species) [taxon 193516], Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** P18 N
- **Cell lines:** B16-F10 — Mus musculus (Mouse), Mouse melanoma, Cancer cell line (CVCL_0159), FaDu — Homo sapiens (Human), Hypopharyngeal squamous cell carcinoma, Cancer cell line (CVCL_1218), MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031), U937 — Homo sapiens (Human), Adult acute monocytic leukemia, Cancer cell line (CVCL_0007), VCaP — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_2235), HL-60 — Homo sapiens (Human), Adult acute myeloid leukemia with maturation, Cancer cell line (CVCL_0002), LNCaP — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_0395), PNT2 — Homo sapiens (Human), Transformed cell line (CVCL_2164), PC3 — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_0035), A549 lung cancer — Homo sapiens (Human), Lung squamous cell carcinoma, Cancer cell line (CVCL_3008), HeLa cervical cancer — Homo sapiens (Human), Human papillomavirus-related endocervical adenocarcinoma, Cancer cell line (CVCL_JX14), THP-1 — Homo sapiens (Human), Childhood acute monocytic leukemia, Cancer cell line (CVCL_0006)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12940976/full.md

## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12940976/full.md

---
Source: https://tomesphere.com/paper/PMC12940976