# Special Issue “Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 3rd Edition”

**Authors:** Zhidong Zhou, Alexandre Hiroaki Kihara

PMC · DOI: 10.3390/ijms27041980 · International Journal of Molecular Sciences · 2026-02-19

## Full-text entities

- **Genes:** NLRP3 (NLR family pyrin domain containing 3) [NCBI Gene 114548] {aka AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, GBA1 (glucosylceramidase beta 1) [NCBI Gene 2629] {aka GBA, GCB, GLUC}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, ISYNA1 (inositol-3-phosphate synthase 1) [NCBI Gene 51477] {aka INO1, INOS, IPS, IPS 1, IPS-1}, Gpr55 (G protein-coupled receptor 55) [NCBI Gene 227326] {aka CTFL, Gm218, Lpir1}, GFAP (glial fibrillary acidic protein) [NCBI Gene 2670] {aka ALXDRD}, SNCA (synuclein alpha) [NCBI Gene 6622] {aka NACP, PARK1, PARK4, PD1}, LRRK2 (leucine rich repeat kinase 2) [NCBI Gene 120892] {aka AURA17, DARDARIN, PARK8, RIPK7, ROCO2}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}, HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}
- **Diseases:** PD (MESH:D010300), Mitochondrial dysfunction (MESH:D028361), Neurodegenerative Diseases (MESH:D019636), injury to (MESH:D014947), Inflammatory (MESH:D007249), Astrogliosis (MESH:D005911), synucleinopathies (MESH:D000080874), Neuroinflammation (MESH:D000090862), neuropsychiatric symptoms (MESH:D001523), AD (MESH:D000544), neurotoxicity (MESH:D020258), PSP (MESH:D011030), amyloid (MESH:C000718787), Parkinson (MESH:D010302), locus coeruleus degeneration (MESH:D009410), cognitive decline (MESH:D003072), movement disorders (MESH:D009069), REM sleep behavior disorder (MESH:D020187), motor dysfunction (MESH:D000068079), multiple sclerosis (MESH:D009103), PSP-P (MESH:D013494), cerebellar hyperexcitability (MESH:D002526)
- **Chemicals:** palmitoylethanolamide (MESH:C005958), caffeine (MESH:D002110), Glutamatergic (-), LPS (MESH:D008070), cladribine (MESH:D017338), endocannabinoid (MESH:D063388), Ethanol (MESH:D000431), CBD (MESH:D002185), Noradrenaline (MESH:D009638)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** HMC3 — Homo sapiens (Human), Transformed cell line (CVCL_II76)

## Full text

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12940710/full.md

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Source: https://tomesphere.com/paper/PMC12940710