# Socioeconomic and Clinical Risk Factors for Meconium-Stained Amniotic Fluid and Associated Maternal–Neonatal Morbidity in Ethiopia: A Prospective Case–Control Study

**Authors:** Loris Marin, Guido Ambrosini, Elisabetta Valentini, Jordyn Conley, Alessandra Andrisani

PMC · DOI: 10.3390/ijerph23020231 · International Journal of Environmental Research and Public Health · 2026-02-11

## TL;DR

This study in Ethiopia identifies socioeconomic and clinical factors linked to meconium-stained amniotic fluid and its impact on maternal and neonatal health.

## Contribution

The study highlights unique socioeconomic risk factors for meconium-stained amniotic fluid in a low-income setting.

## Key findings

- Women with MSAF had significant differences in travel distance, transportation, and family income.
- Higher rates of intrapartum monitoring abnormalities and operative deliveries were observed in MSAF cases.
- Socioeconomic factors appear to influence the occurrence of MSAF in this population.

## Abstract

Meconium-stained amniotic fluid (MSAF) results from premature release of meconium by the fetus under stressful conditions and is associated with increased risk of maternal and neonatal morbidity and mortality. Risk factors for stressful conditions may differ between women living in highly developed countries and those in low-income countries. This study aimed to evaluate known and potential risk factors for MSAF and to assess the association between MSAF and maternal and neonatal morbidity. This prospective case–control study was conducted at a tertiary care hospital in Wolisso, Ethiopia. A total of 165 women were enrolled and divided into two groups: group A (65 women with MSAF) and group B (100 women with clear amniotic fluid). Data were collected through medical records (pregnancy, maternal and fetal outcomes) and questionnaires (socioeconomic factors). Women with MSAF had statistically significant differences in distance traveled, means of transportation, travel time to reach the hospital, weekly workload, and family income compared to controls. Higher rates of intrapartum monitoring abnormalities and operative deliveries were also observed among women with MSAF. The socioeconomic situation of pregnant women referred to the hospital in Wolisso appears to be related to the occurrence of MSAF. Recognizing these risk factors is crucial to improving quality of care and maternal–fetal health.

## Full-text entities

- **Diseases:** preeclampsia (MESH:D011225), Labor dystocia (MESH:D004420), fetal growth restriction (MESH:D005317), Oligohydramnios (MESH:D016104), injury to (MESH:D014947), intrahepatic cholestasis (MESH:D002780), fever (MESH:D005334), respiratory distress (MESH:D012128), gestational diabetes (MESH:D016640), weight gain (MESH:D015430), Fetal tachycardia (MESH:D005315), infections (MESH:D007239), hypoglycemia (MESH:D007003), tachypnea (MESH:D059246), PROM (MESH:D005322), dehydration (MESH:D003681), outcomes (MESH:D011248), MSAF (MESH:D004619), maternal (MESH:D000079262), prolonged labor (MESH:D008133), chorioamnionitis (MESH:D002821), pregnancy (MESH:D011254), MAS (MESH:D008471), fetal distress (MESH:D005316)
- **Chemicals:** lactate (MESH:D019344), cocaine (MESH:D003042), castor oil (MESH:D002368), isihlambezo (-), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12940557/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12940557/full.md

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Source: https://tomesphere.com/paper/PMC12940557