# Impact of Depression, Anxiety, and Stress on Mental Health Among Peruvian Healthcare Professionals

**Authors:** Diego Ismael Valencia-Pecho, Silvana Varela-Guevara, Miguel Basauri-Delgado, Jacksaint Saintila

PMC · DOI: 10.3390/healthcare14040490 · Healthcare · 2026-02-14

## TL;DR

This study explores how depression, anxiety, and stress affect the mental health of healthcare professionals in Peru, finding strong negative correlations.

## Contribution

The study quantifies the significant inverse relationship between mental health and symptoms of depression, anxiety, and stress in healthcare professionals.

## Key findings

- Over 80% of healthcare professionals showed mild depression and stress symptoms.
- Mental health was strongly inversely correlated with depression (r = −0.706), anxiety (r = −0.742), and stress (r = −0.698).
- A predictive model explained 59.2% of the variance in mental health outcomes.

## Abstract

Background: Mental health among healthcare professionals is a critical aspect of clinical practice, as they are exposed to demanding working conditions that frequently lead to symptoms of depression, anxiety, and stress. Objective: We aimed to examine the influence of depression-, anxiety-, and stress-related symptoms on mental health in healthcare professionals. Methods: A quantitative, non-experimental, cross-sectional study was conducted with a sample of 123 healthcare professionals from a Peruvian hospital. Two instruments were administered: the Depression, Anxiety, and Stress Scale (DASS-21) and the Mental Health Inventory–5 (MHI-5). Results: More than 75% of healthcare professionals presented mild levels of depression (82.1%) and stress (89.4%), whereas over half reported mild levels of anxiety (63.4%). Significant differences were observed according to age and years of service (p < 0.05). Mental health was significantly and inversely correlated with depression (r = −0.706), anxiety (r = −0.742), and stress (r = −0.698). Moreover, the predictive model explained 59.2% of the variance, with a moderate effect size. Conclusions: Among healthcare professionals, higher levels of depression, anxiety, and stress were associated with significantly lower mental health. The strength of these correlations highlights the need to better understand and address the negative emotional impact experienced by healthcare personnel.

## Full-text entities

- **Diseases:** Anxiety (MESH:D001007), Depression (MESH:D003866)

## Full text

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC12940484/full.md

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Source: https://tomesphere.com/paper/PMC12940484