# Special Issue “Molecular and Cellular Research in Pregnancy-Related Complications”

**Authors:** Regina Komsa-Penkova

PMC · DOI: 10.3390/ijms27041734 · International Journal of Molecular Sciences · 2026-02-11

## Full-text entities

- **Genes:** MAPK1 (mitogen-activated protein kinase 1) [NCBI Gene 5594] {aka ERK, ERK-2, ERK2, ERT1, MAPK2, NS13}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MIR222 (microRNA 222) [NCBI Gene 407007] {aka MIRN222, miRNA222, mir-222}, MPO (myeloperoxidase) [NCBI Gene 4353], MIR32 (microRNA 32) [NCBI Gene 407036] {aka MIRN32, hsa-mir-32, miR-32, miRNA32}, TLE6 (TLE family member 6, subcortical maternal complex member) [NCBI Gene 79816] {aka GRG6, OZEMA15, PREMBL}, NLRP7 (NLR family pyrin domain containing 7) [NCBI Gene 199713] {aka CLR19.4, HYDM, NALP7, NOD12, OZEMA25, PAN7}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, FSHR (follicle stimulating hormone receptor) [NCBI Gene 2492] {aka FSHR1, FSHRO, LGR1, ODG1}, MIR146A (microRNA 146a) [NCBI Gene 406938] {aka MIRN146, MIRN146A, miR-146a, miRNA146A}, MIR125A (microRNA 125a) [NCBI Gene 406910] {aka MIRN125A, miRNA125A, mir-125a}, ENG (endoglin) [NCBI Gene 2022] {aka END, HHT1, ORW1}, NOS3 (nitric oxide synthase 3) [NCBI Gene 4846] {aka EC-NOS, ECNOS, MYMY8, NOSIII, cNOS, eNOS}, MIR25 (microRNA 25) [NCBI Gene 407014] {aka MIRN25, hsa-mir-25, miR-25}, ABCB1 (ATP binding cassette subfamily B member 1) [NCBI Gene 5243] {aka ABC20, CD243, CLCS, ENPAT, GP170, MDR1}, PGF (placental growth factor) [NCBI Gene 5228] {aka D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760}, FLT1 (fms related receptor tyrosine kinase 1) [NCBI Gene 2321] {aka FLT, FLT-1, VEGFR-1, VEGFR1}, TLR4 (toll like receptor 4) [NCBI Gene 7099] {aka ARMD10, CD284, TLR-4, TOLL}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, INSR (insulin receptor) [NCBI Gene 3643] {aka CD220, HHF5}, SAA [NCBI Gene 6287], PGP (phosphoglycolate phosphatase) [NCBI Gene 283871] {aka AUM, G3PP, PGPase}
- **Diseases:** Related Complications (MESH:D048909), hypertensive (MESH:D006973), Pregnancy Complications (MESH:D011248), gestational hypertension (MESH:D046110), cardiovascular disease (MESH:D002318), RPL (MESH:D000026), Placental Dysfunction (MESH:D010922), pregnancy loss (MESH:D000022), Maternal Obesity (MESH:D000079262), complications (MESH:D008107), inflammatory (MESH:D007249), injury to (MESH:D014947), restricted growth (MESH:D005317), congenital anomalies (MESH:D000013), PE (MESH:D011225), endothelial dysfunction (MESH:D014652), obese (MESH:D009765), multi-organ syndrome (MESH:D009102), GDM (MESH:D016640), hypoxia (MESH:D000860), metabolic dysfunction (MESH:D008659)
- **Chemicals:** vitamins C and E (-), NO (MESH:D009614), malondialdehyde (MESH:D008315), 8-isoprostane (MESH:C075750), ROS (MESH:D017382), oxygen (MESH:D010100), 8-hydroxy-2'-deoxyguanosine (MESH:D000080242)
- **Species:** Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]
- **Mutations:** rs2071409, rs2243828

## Full text

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## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12940365/full.md

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Source: https://tomesphere.com/paper/PMC12940365