Unraveling the Cold Property of Gardeniae Fructus: Material Basis and Biological Mechanisms
Chao Yang, Shuyao Wu, Xiao Huang, Zhigui Wu, Yuying Fan, Xilan Liu, Rui Zhong, Yifei Rao, Jing Liu, Xiaomei Fu
TL;DR
This study identifies key chemical fractions in Gardeniae Fructus that may explain its 'cold' property in traditional Chinese medicine by affecting metabolism, the nervous system, and gut microbes.
Contribution
The study identifies specific chemical fractions in Gardeniae Fructus responsible for its 'cold' property through biological and microbiome mechanisms.
Findings
Iridoid, crocin, and polysaccharide fractions showed significant cold properties in a rat model.
The iridoid fraction had the strongest effect on modulating metabolism and gut microbiota.
Total extract and certain fractions reduced Firmicutes and Lactobacillus in gut microbiota.
Abstract
In traditional Chinese medicine (TCM), Gardeniae Fructus is classified as a “cold” herb, a property that is increasingly explained by modern research showing that it can alleviate related disorders through modulation of the central nervous and endocrine systems, energy metabolism, and gut microbiota. This study aimed to elucidate the material foundation and biological mechanisms underlying its cold property. Chemical components of Gardeniae Fructus were separated via multi-stage extraction and characterized by GC-MS and LC-MS, yielding four distinct fractions: aliphatic, iridoid, crocin, and polysaccharide. In a rat model of heat syndrome induced by levothyroxine sodium, administration of the total extract or individual fractions over 15 days modulated central nervous, endocrine, and energy metabolism indicators, with the iridoid, crocin, and polysaccharide fractions demonstrating…
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Taxonomy
TopicsSaffron Plant Research Studies · Traditional Chinese Medicine Analysis · Medicinal Plants and Bioactive Compounds