Actively expressed microbiota in mucosal biopsies of treatment-naïve ulcerative colitis patients
Line Strand Karlsholm, Rafi Ahmad, Hagar Taman, Christopher G. Fenton, Ruth H. Paulssen
TL;DR
This study examines the gut microbiota in ulcerative colitis patients to understand how microbial changes at the site of inflammation may contribute to disease development.
Contribution
The study provides new insights into the microbial composition at the site of inflammation in treatment-naïve ulcerative colitis patients.
Findings
UC patient samples showed decreased microbial diversity compared to controls.
Opportunistic pathogens Acinetobacter and Comamonas were increased in UC samples.
Comamonas may play a role in active ulcerative colitis.
Abstract
The gut microbiota contributes to an aberrant immune dysfunction associated with inflammatory bowel disease (IBD) and is believed to contribute to the disease development of ulcerative colitis (UC). In this study, a whole-transcriptomic data set containing mucosal tissue biopsies obtained from treatment-naïve UC patients (n = 33) and control subjects (n = 15) were utilized to determine potential differences in microbial compositions located at the site of inflammation. Transcriptomic sequences that mapped to the human genome were removed from the dataset. The remaining were mapped to their respective Operational Taxonomic Units (OTUs) resulting in an overview of the microbial composition at the genus level. Results showed an overall decrease in microbial diversity in mucosal UC patient samples. However, an increase of the opportunistic pathogens Acinetobacter and Comamonas was observed…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsInflammatory Bowel Disease · Microscopic Colitis · Gut microbiota and health