# Smart Composite Hydrogels for Monitoring and Managing Chronic Wounds

**Authors:** Jun Zhu, Yibin Huang, Junbo Tong, Antong Li, Bin Chu

PMC · DOI: 10.3390/gels12020120 · 2026-01-29

## TL;DR

This paper reviews smart hydrogels that can monitor chronic wounds in real-time, offering a new approach to wound management.

## Contribution

The paper introduces composite hydrogels with functional fillers for intelligent wound monitoring and personalized treatment.

## Key findings

- Composite hydrogels can sense key wound parameters in real-time.
- Multimodal monitoring systems are being developed for different chronic wound types.
- Future directions aim at personalized intelligent wound management systems.

## Abstract

The precise management of chronic wounds poses a global medical challenge, owing to their complex and dynamically shifting pathological microenvironment, coupled with their inherent difficulty in healing. Traditional dressings, which lack capabilities for real-time monitoring and active intervention, fall short of meeting modern clinical needs. Composite hydrogels offer a novel solution to this problem. By integrating functional fillers within biocompatible hydrogel matrices, they form intelligent materials capable of sensing key wound parameters. This review systematically outlines the composite systems and material classification of such hydrogels designed for the intelligent monitoring of chronic wounds. It subsequently details the construction of multimodal monitoring systems and their applications across different types of chronic wounds., Finally, future development direction are discussed, aiming to advance the implementation of next generation, personalized intelligent wound management systems.

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, FGF2 (fibroblast growth factor 2) [NCBI Gene 2247] {aka BFGF, FGF-2, FGFB, HBGF-2}
- **Diseases:** diabetes (MESH:D003920), edema (MESH:D004487), Chronic Wounds (MESH:D014947), inflammation (MESH:D007249), peripheral vascular disease (MESH:D016491), fibrosis (MESH:D005355), hyperglycemia (MESH:D006943), ischemia (MESH:D007511), metabolic diseases (MESH:D008659), hypoxia (MESH:D000860), fatigue (MESH:D005221), diabetic neuropathy (MESH:D003929), infection (MESH:D007239), infected wounds (MESH:D014946), toxicity (MESH:D064420), ulcers (MESH:D014456), DFU (MESH:D017719), reperfusion injury (MESH:D015427), PI (MESH:D003668), necrosis (MESH:D009336), atopic dermatitis (MESH:D003876), skin defect (MESH:D012868), bacterial infection (MESH:D001424)
- **Chemicals:** hexaethylene glycol (MESH:C077067), polysaccharides (MESH:D011134), TA (MESH:D013635), MOF (MESH:D000073396), PPy (MESH:C067635), GO (MESH:C000628730), PEG (MESH:D011092), beta-CD (MESH:C031215), azide (MESH:D001386), ciprofloxacin (MESH:D002939), Carbon (MESH:D002244), polyelectrolyte (MESH:D000071228), PAAm (MESH:C016679), Polymer (MESH:D011108), Metal (MESH:D008670), polyethylene glycol diacrylate (MESH:C437167), sodium phytate (MESH:D010833), PPA (MESH:C016071), gold (MESH:D006046), COO (MESH:C041069), Chitosan (MESH:D048271), antimicrobial peptides (MESH:D000089882), thioether (MESH:D013440), oxygen (MESH:D010100), kappa-carrageenan (MESH:D002351), Alginate (MESH:D000464), calcium phosphate (MESH:C020243), Ag (MESH:D012834), RES (MESH:D000077185), polydopamine (MESH:C568283), copper (MESH:D003300), CMCS (MESH:C514968), -acrylamide (MESH:D020106), hemicellulose (MESH:C007916), poly (3,4-ethylenedioxythiophene) (MESH:C121383), hyaluronic acid (MESH:D006820), Schiff base (MESH:D012545), zinc oxide (MESH:D015034), E (MESH:D004540), water (MESH:D014867), PANI (MESH:C416807), tyrosine (MESH:D014443), iron (MESH:D007501), (+) -catechin (MESH:D002392), PEDOT: PSS (MESH:C533756), PAA-CD (MESH:C006903), PVA (MESH:D011142), CNT (MESH:D037742), poly (sulfobetaine methacrylate) (MESH:C521589), asbestos (MESH:D001194), starch (MESH:D013213), AM-IL (-), hydrogen peroxide (MESH:D006861), CNF (MESH:C071110), dextran (MESH:D003911), phenol red (MESH:D010637), poly (2-(dimethylamino)ethyl methacrylate) (MESH:C407037), Pluronic F127 (MESH:D020442), glycerol (MESH:D005990), CB (MESH:C063451)
- **Species:** Escherichia coli (E. coli, species) [taxon 562], Rattus norvegicus (brown rat, species) [taxon 10116], Staphylococcus aureus (species) [taxon 1280], Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12940069/full.md

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Source: https://tomesphere.com/paper/PMC12940069