Cherubism: An African-Focused Review
Salma Kabbashi, Imaan A. Roomaney, Martin Douglas-Jones, Karen Fieggen, Nakita Laing, Suvarna Indermun, Manogari Chetty

TL;DR
This review highlights the limited understanding of cherubism in Africa, emphasizing the need for better data collection and genetic testing to improve patient care and global knowledge.
Contribution
The paper provides a focused review of cherubism in African populations, identifying gaps in diagnosis, genetic testing, and long-term follow-up.
Findings
Cherubism in Africa is underreported and lacks accurate epidemiological data.
Delayed specialist care leads to significant complications in affected individuals.
Molecular genetic testing is rarely used, with most diagnoses relying on clinical and radiological features.
Abstract
What are the main findings? The epidemiology of cherubism in Africa cannot be accurately determined from the currently available published data.Although symptom onset typically occurs in early childhood, presentation for specialist care is often delayed until adolescence, with significant complications reported. The epidemiology of cherubism in Africa cannot be accurately determined from the currently available published data. Although symptom onset typically occurs in early childhood, presentation for specialist care is often delayed until adolescence, with significant complications reported. What are the implications of the main findings? There is a need for registries and publications on the long term follow up of patients with cherubism to better understand if the natural history of cherubism and whether the phenotype differs from what has been reported in other regions.Enhancing…
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Taxonomy
TopicsBone Tumor Diagnosis and Treatments · Oral and Maxillofacial Pathology · Heterotopic Ossification and Related Conditions
