# Adaptive Bandelet Transform and Transfer Learning for Geometry-Aware Thyroid Cancer Ultrasound Classification

**Authors:** Yassine Habchi, Hamza Kheddar, Mohamed Chahine Ghanem, Jamal Hwaidi

PMC · DOI: 10.3390/diagnostics16040554 · 2026-02-13

## TL;DR

This paper introduces a new method for thyroid cancer classification in ultrasound images by combining a geometry-adaptive Bandelet Transform with transfer learning, achieving high accuracy with limited data.

## Contribution

The novel integration of geometry-adaptive Bandelet Transform with transfer learning improves data-efficient classification of thyroid nodules in ultrasound.

## Key findings

- The proposed BT+TL (VGG19) model achieves 98.91% accuracy on the DDTI dataset.
- BT-based preprocessing outperforms classical wavelet representations across multiple thresholds.
- The model shows high sensitivity (98.11%) and specificity (97.31%) for thyroid nodule classification.

## Abstract

Background and Objectives: Classification of thyroid nodules (TN) in ultrasound remains challenging due to limited labelled data and the limited capacity of conventional feature representations to capture complex, multi-directional textures. This work aims to improve data-efficient TN classification by integrating a geometry-adaptive Bandelet Transform (BT) with transfer learning (TL) to enhance feature representation and generalisation. Methods: The proposed pipeline first applies BT to strengthen directional and structural encoding in ultrasound images via quadtree-driven geometric adaptation. It then mitigates class imbalance using SMOTE and increases data diversity through targeted data augmentation. The resulting representations are classified using multiple ImageNet-pretrained architectures, where VGG19 yields the most consistent performance. Results: Experiments on the publicly available DDTI dataset show that BT-based preprocessing consistently improves performance over classical wavelet representations across multiple quadtree thresholds, with the best results obtained at T=30. Under this setting, the proposed BT+TL (VGG19) model achieves 98.91% accuracy, 98.11% sensitivity, 97.31% specificity, and a 98.89% F1-score, outperforming comparable approaches reported in the literature. Conclusions: Coupling geometry-adaptive transforms with modern TL backbones provides a robust and data-efficient strategy for ultrasound TN classification, particularly under limited annotation and challenging texture variability. The complete project is publicly available.

## Linked entities

- **Diseases:** thyroid cancer (MONDO:0002108)

## Full-text entities

- **Diseases:** lymph node metastasis (MESH:D008207), thyroid abnormalities (MESH:D013959), thyroid and breast lesions (MESH:D001941), TC (MESH:D013964), metastasis (MESH:D009362), WT (MESH:D002472), adenoma (MESH:D000236), DL (MESH:D007859), papillary thyroid cancer (MESH:D000077273), thyroid (MESH:D013966), TN (MESH:D016606), injury to (MESH:D014947), cancer (MESH:D009369), thyroid adenocarcinoma (MESH:D000230)
- **Chemicals:** DDTI (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** VGG19 — Homo sapiens (Human), Prostate carcinoma, Cancer cell line (CVCL_5989)

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12939836/full.md

---
Source: https://tomesphere.com/paper/PMC12939836