# The Intersection of Non-Communicable Chronic Disease and Endodontic Care: A Pilot Retrospective Cross-Sectional Study

**Authors:** Fausto Zamparini, Mohamed Mowafy, Andrea Spinelli, Stefano Chersoni, Igor Diemberger, Antonella Polimeni, Maria Giovanna Gandolfi, Carlo Prati

PMC · DOI: 10.3390/dj14020074 · 2026-02-02

## TL;DR

This study found that over a third of patients receiving endodontic treatment have chronic diseases, highlighting the need for personalized dental care.

## Contribution

The study provides new insights into the prevalence of systemic chronic diseases among endodontic patients and their treatment implications.

## Key findings

- 35% of patients had at least one chronic systemic disease or multiple comorbidities.
- Cardiovascular diseases were the most common, affecting 19.8% of patients.
- Polypharmacy was observed in 32% of patients, with older patients more likely to have chronic conditions.

## Abstract

Objective: To evaluate the prevalence of systemic chronic diseases among patients undergoing endodontic therapy in a University Department of Endodontology and to assess their potential implications for treatment planning and prognosis. Methods: A retrospective cross-sectional study analysis was performed on clinical records of patients aged > 18 years treated at the Department of Endodontics, University of Bologna. Data collected included demographic information, presence of chronic systemic diseases, endodontic disease and medication history. Descriptive statistics were used to estimate prevalence rates. Results: More than one third of patients (35%) presented with at least one systemic chronic disease or multiple comorbidities. Cardiovascular diseases (19.8%) were the most prevalent. Polypharmacy was observed in 32% of patients. Patients aged 40 years and older showed a significantly higher prevalence of systemic conditions compared to younger individuals. Conclusions: The study supports the finding that a high percentage of patients undergoing endodontic therapies present systemic chronic diseases, multiple comorbid conditions and polypharmacy. It is important to assess these factors and to customize endodontic treatment and decision-making. These realities are likely to become even more pronounced in the coming years, as global population aging continues apace.

## Full-text entities

- **Diseases:** respiratory disease (MESH:D012140), fractures (MESH:D050723), pain (MESH:D010146), pulp necrosis (MESH:D003790), autoimmune/inflammatory (MESH:D007249), hypercementosis (MESH:D006936), cardiocirculatory conditions (MESH:D020763), injury to (MESH:D014947), Cardiocirculatory diseases (MESH:D004194), cardiovascular, endocrine/metabolic, (MESH:D024821), apical periodontitis (MESH:D010485), calcification (MESH:D002114), diabetes mellitus (MESH:D003920), Chronic non-communicable diseases (MESH:D000073296), periapical lesions (MESH:D010483), respiratory condition (MESH:D012131), bleeding (MESH:D006470), autoimmune diseases (MESH:D001327), systemic diseases (MESH:D034721), non (MESH:C580335), metabolic disorders (MESH:D008659), ankylosis (MESH:D000844), deaths (MESH:D003643), hypertension (MESH:D006973), carious lesions (MESH:D003731), osteonecrosis of the jaw (MESH:D059266), osteoporosis (MESH:D010024), congenital heart disease (MESH:D006330), Cardiovascular diseases (MESH:D002318), endocrine and metabolic conditions (MESH:D004700), bacteremia (MESH:D016470), gastrointestinal, hematologic, and neurologic conditions (MESH:D005767), endodontic disease (MESH:D011671), Musculoskeletal disorders (MESH:D009140), thyroid disorders (MESH:D013959), diabetes types 1 and 2 (MESH:D003924), renal disorders (MESH:D007674), rheumatic heart disease (MESH:D012214), Chronic (MESH:D002908), oncologic (MESH:D000072716), necrotic (MESH:D009336)
- **Chemicals:** cardiocirculatory drug (-), Bisphosphonates (MESH:D004164)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12939834/full.md

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Source: https://tomesphere.com/paper/PMC12939834